Hydroxychloroquine

631 interactions 1 explained in plain English 236 cited references

Also sold as: Plaquenil Plaquenil® Sovuna

About Hydroxychloroquine

Hydroxychloroquine is an antimalarial and antirheumatic drug used to prevent and treat malaria, lupus, and rheumatoid arthritis. Read the full Hydroxychloroquine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Bepridil Ziprasidone Mesoridazine Levoketoconazole Cisapride Aurothioglucose

13 Contraindicated 616 Major 2 Moderate

All (631) Contraindicated (13) Major (616) Moderate (2)

Major

Hydroxychloroquine Doxylamine Aldex AN An increased risk of seizures Details Hydroxychloroquine Droperidol An increased risk of seizures and an increased risk of QT interval prolongation Details Hydroxychloroquine Dulaglutide Trulicity Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Hydroxychloroquine Ebastine An increased risk of seizures and an increased risk of QT interval prolongation Details Hydroxychloroquine Echothiophate An increased risk of seizures Details Hydroxychloroquine Efavirenz An increased risk of QT interval prolongation Details Hydroxychloroquine Emedastine An increased risk of seizures Details Hydroxychloroquine Enflurane An increased risk of seizures Details Hydroxychloroquine Enoxacin An increased risk of seizures Details Hydroxychloroquine Epinastine An increased risk of seizures Details Hydroxychloroquine Eribulin Halaven Increased risk of QT interval prolongation Details Hydroxychloroquine Erythromycin Erythrocin Stearate Increased risk of QT interval prolongation Details Hydroxychloroquine Escitalopram Lexapro An increased risk of seizures and an increased risk of QT interval prolongation Details Hydroxychloroquine Eslicarbazepine Acetate Aptiom Impaired antiepileptic activity Details Hydroxychloroquine Esterified Estrogens Menest An increased risk of seizures Details Hydroxychloroquine Estriol An increased risk of seizures Details Hydroxychloroquine Estrone An increased risk of seizures Details Hydroxychloroquine Estropipate Ogen An increased risk of seizures Details Hydroxychloroquine Ethinyl Estradiol An increased risk of seizures Details Hydroxychloroquine Ethopropazine An increased risk of seizures Details Hydroxychloroquine Etrasimod Velsipity Increased risk of transient reduction in heart rate, AV conduction, QT interval prolongation and an increased risk of torsade de p... Details Hydroxychloroquine Exenatide Bydureon Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Hydroxychloroquine Femoxetine An increased risk of seizures Details Hydroxychloroquine Fentanyl An increased risk of seizures Details Hydroxychloroquine Fesoterodine Toviaz An increased risk of seizures Details Hydroxychloroquine Fexinidazole An increased risk of QT interval prolongation Details Hydroxychloroquine Fingolimod Gilenya Increased risk of QT interval prolongation Details Hydroxychloroquine Flavoxate An increased risk of seizures Details Hydroxychloroquine Flucloxacillin An increased risk of seizures Details Hydroxychloroquine Fluconazole Diflucan Increased risk of QT interval prolongation Details Hydroxychloroquine Flumequine An increased risk of seizures Details Hydroxychloroquine Flunarizine An increased risk of seizures Details Hydroxychloroquine Fluoxetine RECONCILE Increased risk of QT interval prolongation Details Hydroxychloroquine Fluphenazine An increased risk of seizures Details Hydroxychloroquine Fluvoxamine An increased risk of seizures Details Hydroxychloroquine Formoterol Perforomist Increased risk of QT interval prolongation Details Hydroxychloroquine Foscarnet Foscavir An increased risk of seizures and an increased risk of QT interval prolongation Details Hydroxychloroquine Fosfomycin Contepo An increased risk of QT interval prolongation Details Hydroxychloroquine Fosphenytoin Cerebyx Increased risk of QT interval prolongation Details Hydroxychloroquine Fosphenytoin Sodium Impaired antiepileptic activity Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.