Hydroxychloroquine

631 interactions 1 explained in plain English 236 cited references

Also sold as: Plaquenil Plaquenil® Sovuna

About Hydroxychloroquine

Hydroxychloroquine is an antimalarial and antirheumatic drug used to prevent and treat malaria, lupus, and rheumatoid arthritis. Read the full Hydroxychloroquine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Bepridil Ziprasidone Mesoridazine Levoketoconazole Cisapride Aurothioglucose

13 Contraindicated 616 Major 2 Moderate

All (631) Contraindicated (13) Major (616) Moderate (2)

Major

Hydroxychloroquine Isoflurophate An increased risk of seizures Details Hydroxychloroquine Isoniazid An increased risk of seizures Details Hydroxychloroquine Isopropamide An increased risk of seizures Details Hydroxychloroquine Itraconazole Sporanox Increased risk of QT interval prolongation Details Hydroxychloroquine Ivabradine Corlanor Increased risk of QT interval prolongation Details Hydroxychloroquine Ivosidenib Tibsovo An increased risk of QT interval prolongation Details Hydroxychloroquine Kaolin Pet Pectillin Reduced hydroxychloroquine exposure Details Hydroxychloroquine Ketamine An increased risk of seizures Details Hydroxychloroquine Ketoconazole Extina Increased risk of QT interval prolongation Details Hydroxychloroquine Ketotifen Alaway An increased risk of seizures Details Hydroxychloroquine Lacosamide Motpoly Impaired antiepileptic activity Details Hydroxychloroquine Lamotrigine Lamictal Impaired antiepileptic activity Details Hydroxychloroquine Lapatinib Tykerb Increased risk of QT interval prolongation Details Hydroxychloroquine Lefamulin Xenleta Increased risk of QT interval prolongation Details Hydroxychloroquine Lenvatinib Lenvima Increased risk of QT-interval prolongation Details Hydroxychloroquine Leuprolide Eligard Increased risk of QT interval prolongation Details Hydroxychloroquine Levetiracetam Elepsia Impaired antiepileptic activity Details Hydroxychloroquine Levocabastine An increased risk of seizures Details Hydroxychloroquine Levofloxacin Levaquin An increased risk of seizures and an increased risk of QT interval prolongation Details Hydroxychloroquine Levomilnacipran An increased risk of seizures Details Hydroxychloroquine Levorphanol Xyvona An increased risk of seizures Details Hydroxychloroquine Lidocaine Akten An increased risk of seizures Details Hydroxychloroquine Linagliptin Tradjenta Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Hydroxychloroquine Lindane Gamene® An increased risk of seizures Details Hydroxychloroquine Liraglutide Saxenda Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Hydroxychloroquine Lisdexamfetamine Arynta An increased risk of seizures, increased dextroamphetamine or lisdexamfetamine (prodrug of dextroamphetamine) exposure and an incr... Details Hydroxychloroquine Lithium An increased risk of seizures Details Hydroxychloroquine Lixisenatide Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Hydroxychloroquine Lofepramine An increased risk of seizures Details Hydroxychloroquine Lofexidine Increased risk of QT interval prolongation Details Hydroxychloroquine Lomefloxacin An increased risk of seizures Details Hydroxychloroquine Lonafarnib Zokinvy An increased risk of QT interval prolongation and torsade de pointes Details Hydroxychloroquine Loperamide Diamode An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Hydroxychloroquine Lorazepam Ativan Impaired antiepileptic activity Details Hydroxychloroquine Loxapine Adasuve An increased risk of seizures Details Hydroxychloroquine Lumefantrine Increased risk of QT interval prolongation Details Hydroxychloroquine Macimorelin Increased risk of QT interval prolongation Details Hydroxychloroquine Magaldrate Reduced hydroxychloroquine exposure Details Hydroxychloroquine Magnesium Carbonate Reduced hydroxychloroquine exposure Details Hydroxychloroquine Magnesium Hydroxide Almacone® (containing Aluminum Hydroxide, Magnesium Hydroxide, Simethicone) Reduced hydroxychloroquine exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.