Drug Interaction Report

Lixisenatide Injection and Acetaminophen: Interaction Details

A pharmacist-reviewed analysis of the Lixisenatide Injection and Acetaminophen interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Lixisenatide Injection

Adlyxin® Soliqua® (as a combination product containing Insulin Glargine and Lixisenatide)
+

Acetaminophen

Acephen Actamin® Anacin AF Bactimicina Cetafen Comtrex Sore Throat Relief CounterAct Pain Feverall
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Aug 8, 2026
Editorial policy · Data sources
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Interaction severity
Moderate
Can be significant — usually manageable with monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 174 documented Lixisenatide Injection interactions, 120 are rated moderate — including this one.
Onset
delayed
Evidence
probable
Severity
Moderate

What happens

Slowed absorption of acetaminophen

Interaction Deep Dive

Use of acetaminophen following lixisenatide administration may slow the absorption of acetaminophen due to delayed gastric emptying. While no change in acetaminophen Cmax or Tmax was observed with acetaminophen administration 1 hour before lixisenatide, acetaminophen Cmax decreased by nearly one-third and Tmax was delayed by about 2 hours with administration 1 and 4 hours after lixisenatide. If concomitant use of these agents is required, administer acetaminophen at least 1 hour before lixisenatide to avoid the delay in effect of acetaminophen1.

Why it happens (mechanism)

Delayed gastric emptying

Literature reports

1 report — tap to read

a) Administration of a single dose of acetaminophen 1000 mg before or after lixisenatide 10 mcg did change acetaminophen AUC. When acetaminophen was administered 1 hour before lixisenatide, no effects on acetaminophen Cmax and Tmax were observed; however, when administered 1 and 4 hours after lixisenatide 10 mcg, Cmax of acetaminophen was decreased by 29% and 31%, respectively, and median Tmax was delayed by 2 and 1.75 hours, respectively 1.

Common questions

Can I take Lixisenatide Injection and Acetaminophen together?

Slowed absorption of acetaminophen Always confirm with your pharmacist or prescriber before making any change.

How serious is the Lixisenatide Injection and Acetaminophen interaction?

It is rated moderate. Can be significant — usually manageable with monitoring.

How quickly could this interaction happen?

The documented onset is "delayed". Effects tend to build up gradually over days to weeks.

How strong is the evidence for this interaction?

The evidence is graded "probable". Good supporting evidence, though not definitively proven.

Questions for your pharmacist

  • Does my dose of Lixisenatide Injection or Acetaminophen need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there anything you'd monitor while I'm on both?

References (1)

  1. Product Information: ADLYXIN(TM) subcutaneous injection, lixisenatide subcutaneous injection. sanofi-aventis US LLC (per manufacturer), Bridgewater, NJ, 2016. DailyMed
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Lixisenatide Injection

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All Lixisenatide Injection interactions (174) Lixisenatide Injection drug information
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Acetaminophen

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Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Acetaminophen + Activated Charcoal Asarabacca Beer Siberian Cocklebur Wine Adrafinil African Wild Potato Aristolochia + 147 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

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This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.