Metformin

378 interactions 1 explained in plain English 428 cited references
Also sold as: Fortamet® Glucophage Glucophage® Glumetza Glumetza® Riomet Riomet® Trijardy® (as a combination product containing Empagliflozin, Linagliptin, Metformin)
About Metformin

Metformin is a biguanide medication used to help control blood sugar levels in type 2 diabetes. Read the full Metformin drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ofloxacin Otic Ciprofloxacin Cimetidine Arimoclomol Insulin Glulisine (Rdna Origin) Injection Digoxin
99 Major 278 Moderate 1 Minor
All (378) Major (99) Moderate (278) Minor (1)

Moderate

Metformin Nifedipine Adalat® An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Nimodipine Nimotop An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Nisoldipine Sular An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Nitrendipine An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Nomegestrol An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Norepinephrine Bitartrate An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Norethindrone Aygestin An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Norgestimate An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Norgestrel An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Oxprenolol Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metformin Oxymetazoline Hydrochloride An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Ozanimod An increased risk of hypoglycemia Details Metformin Paramethasone An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Patiromer Veltassa Reduced metFORMIN exposure and reduced efficacy of metFORMIN Details Metformin Penbutolol Levatol® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metformin Periciazine An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Perindopril Aceon An increased risk of hypoglycemia Details Metformin Perphenazine An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Phenelzine Nardil An increased risk of hypoglycemia Details Metformin Phenylephrine Hydrochloride An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Phenytoin Dilantin An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Pibrentasvir Altered glycemic control resulting in severe symptomatic hypoglycemia Details Metformin Pindolol Visken® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metformin Piperazine An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Pipotiazine An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Piretanide An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Polyestradiol Phosphate An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Polythiazide An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Practolol Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metformin Prednicarbate An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Prednisolone Flo-Pred® An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Prednisone Deltasone An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Procarbazine An increased risk of hypoglycemia Details Metformin Prochlorperazine An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Promazine An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Promestriene An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Promethazine Phenadoz An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Propiomazine An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Propranolol Hemangeol Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metformin Pseudoephedrine Hydrochloride An increased risk of hyperglycemia and potential loss of glycemic control Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.