Methocarbamol

25 interactions 2 explained in plain English

Also sold as: Atmeksi Robaxin Tanlor

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acetaminophen And Codeine Midazolam Injection Aripiprazole Injection Nalbuphine Injection Levodopa Oral Inhalation Diazepam Rectal

24 Major 1 Moderate

All (25) Major (24) Moderate (1)

Major

Methocarbamol Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of profound sedation, respiratory depression, coma and death Details Methocarbamol Buprenorphine Belbuca Explained Enhanced neuromuscular blocking action and an increased risk of respiratory depression and CNS depression Details Methocarbamol Aripiprazole Injection Abilify An increased risk of CNS depression Details Methocarbamol Asenapine Transdermal Patch Secuado An increased risk of CNS depression Details Methocarbamol Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Methocarbamol Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Methocarbamol Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Methocarbamol Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Methocarbamol Diazepam Nasal Spray Valtoco Additive respiratory depression Details Methocarbamol Diazepam Rectal Diastat Additive respiratory depression Details Methocarbamol Diphenhydramine Injection Banophen An increased risk of CNS depression Details Methocarbamol Diphenhydramine Topical Afterbite with Antihistamine An increased risk of CNS depression Details Methocarbamol Esketamine Nasal Spray Spravato Increased risk of sedation Details Methocarbamol Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Methocarbamol Hydromorphone Injection Dilaudid Increased risk of profound sedation, respiratory depression, coma and death Details Methocarbamol Hydromorphone Rectal available generically Increased risk of profound sedation, respiratory depression, coma and death Details Methocarbamol Lacosamide Injection Motpoly An increased risk of CNS depression Details Methocarbamol Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Methocarbamol Metoclopramide Injection Gimoti Increased risk of CNS depression Details Methocarbamol Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Methocarbamol Midazolam Nasal Spray Nayzilam Additive respiratory depression Details Methocarbamol Midazolam Injection Nayzilam Additive respiratory depression Details Methocarbamol Morphine Injection Astramorph® PF Increased risk of profound sedation, hypotension, coma and respiratory depression Details Methocarbamol Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression; increased risk of paralytic ileus Details

Moderate

Methocarbamol Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.