Methylene Blue

45 interactions 6 explained in plain English
Also sold as: Provayblue
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Contraindicated

Methylene Blue Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of serotonin syndrome and an increased risk of respiratory and CNS depression Details Methylene Blue Amitriptyline Elavil Explained An increased risk of serotonin syndrome (labile blood pressure, hyperthermia, neuromuscular abnormalities, mental status changes,... Details Methylene Blue Sertraline Explained An increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) Details Methylene Blue Deutetrabenazine Austedo Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Methylene Blue Entacapone Comtan Decreased catecholamine metabolism and risk for hypertensive crisis Details Methylene Blue Levodopa Oral Inhalation Inbrija An increased risk of hypertensive crisis Details Methylene Blue Linezolid Injection Zyvox An increased risk of serotonin syndrome (labile blood pressure, hyperthermia, neuromuscular abnormalities, mental status changes,... Details Methylene Blue Maprotiline Ludiomil® An increased risk of serotonin syndrome (labile blood pressure, hyperthermia, neuromuscular abnormalities, mental status changes,... Details Methylene Blue Methyldopa Aldomet® Hypertensive crisis (headache, palpitation, neck stiffness) Details Methylene Blue Methylphenidate Adhansia XR® An increased risk of hypertensive crisis (headache, palpitation, and neck stiffness) Details Methylene Blue Methylphenidate Transdermal Patch Daytrana An increased risk of hypertensive crisis (headache, palpitation, and neck stiffness) Details Methylene Blue Morphine Injection Astramorph® PF Increased risk of the profound sedation, respiratory depression, hypotension, coma and an increased risk of serotonin syndrome Details

Major

Methylene Blue Albuterol Oral Inhalation Accuneb® Explained An increased risk of cardiovascular adverse effects Details Methylene Blue Buprenorphine Belbuca Explained An increased risk of CNS depression and an increased risk of serotonin syndrome or opioid toxicity Details Methylene Blue Atropine Ophthalmic Atropine Care 1% Potential to cause hypertensive crisis Details Methylene Blue Butorphanol Injection Butorphic Increased risk of serotonin syndrome or opioid toxicity Details Methylene Blue Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome or opioid toxicity Details Methylene Blue Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Methylene Blue Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Methylene Blue Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Methylene Blue Diazepam Rectal Diastat Increased risk of CNS depression Details Methylene Blue Dolasetron Anzemet Increased risk of serotonin syndrome Details Methylene Blue Dolasetron Injection Anzemet Increased risk of serotonin syndrome Details Methylene Blue Esketamine Nasal Spray Spravato Increased risk of sedation Details Methylene Blue Fentanyl Transdermal Patch Duragesic® Potentiation of opioid effects and an increased risk of serotonin syndrome Details Methylene Blue Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Methylene Blue Granisetron Injection Granisol Increased risk of serotonin syndrome Details Methylene Blue Hydromorphone Injection Dilaudid An increased risk of serotonin syndrome or opioid toxicity and an increased risk of respiratory and CNS depression Details Methylene Blue Hydromorphone Rectal available generically An increased risk of serotonin syndrome or opioid toxicity and an increased risk of respiratory and CNS depression Details Methylene Blue Lacosamide Injection Motpoly An increased risk of CNS depression Details Methylene Blue Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Methylene Blue Metoclopramide Injection Gimoti Increased risk of hypertensive crisis Details Methylene Blue Metoclopramide Nasal Spray Gimoti Increased risk of hypertensive crisis Details Methylene Blue Nalbuphine Injection Nubain® Increased risk of serotonin syndrome or opioid toxicity Details Methylene Blue Olodaterol Oral Inhalation Striverdi Potentiated cardiovascular effects Details Methylene Blue Palonosetron Injection Aloxi® Increased risk of serotonin syndrome Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.