Methylene Blue

45 interactions 6 explained in plain English
Also sold as: Provayblue
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acetaminophen And Codeine Methyldopa Levodopa Oral Inhalation Entacapone Maprotiline Deutetrabenazine
12 Contraindicated 24 Major 9 Moderate
All (45) Contraindicated (12) Major (24) Moderate (9)

Contraindicated

Methylene Blue Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of serotonin syndrome and an increased risk of respiratory and CNS depression Details Methylene Blue Amitriptyline Elavil Explained An increased risk of serotonin syndrome (labile blood pressure, hyperthermia, neuromuscular abnormalities, mental status changes,... Details Methylene Blue Sertraline Explained An increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) Details Methylene Blue Deutetrabenazine Austedo Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Methylene Blue Entacapone Comtan Decreased catecholamine metabolism and risk for hypertensive crisis Details Methylene Blue Levodopa Oral Inhalation Inbrija An increased risk of hypertensive crisis Details Methylene Blue Linezolid Injection Zyvox An increased risk of serotonin syndrome (labile blood pressure, hyperthermia, neuromuscular abnormalities, mental status changes,... Details Methylene Blue Maprotiline Ludiomil® An increased risk of serotonin syndrome (labile blood pressure, hyperthermia, neuromuscular abnormalities, mental status changes,... Details Methylene Blue Methyldopa Aldomet® Hypertensive crisis (headache, palpitation, neck stiffness) Details Methylene Blue Methylphenidate Adhansia XR® An increased risk of hypertensive crisis (headache, palpitation, and neck stiffness) Details Methylene Blue Methylphenidate Transdermal Patch Daytrana An increased risk of hypertensive crisis (headache, palpitation, and neck stiffness) Details Methylene Blue Morphine Injection Astramorph® PF Increased risk of the profound sedation, respiratory depression, hypotension, coma and an increased risk of serotonin syndrome Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.