Metoprolol

Name: Metoprolol Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

62 interactions 3 explained in plain English

Also sold as: Kapspargo Kapspargo Sprinkle® Lopressor Lopressor® Toprol Toprol® Toprol® XL

About Metoprolol

Metoprolol is a beta blocker used to treat high blood pressure, chest pain, and heart failure. Read the full Metoprolol drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Sertraline Albuterol Oral Inhalation Abiraterone Clonidine Transdermal Patch Olodaterol Oral Inhalation Lacosamide Injection

8 Major 53 Moderate 1 Minor

All (62) Major (8) Moderate (53) Minor (1)

Moderate

Metoprolol Lixisenatide Injection Adlyxin® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metoprolol Meclofenamate Meclodium® Reduced antihypertensive effect Details Metoprolol Mefenamic Acid Ponstel® Reduced antihypertensive effect Details Metoprolol Meloxicam Alloxate Reduced antihypertensive effect Details Metoprolol Meloxicam Injection Alloxate Reduced antihypertensive effect Details Metoprolol Metformin Fortamet® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metoprolol Methimazole Felanorm Altered metabolism of the beta-adrenergic blocker Details Metoprolol Methyldopa Aldomet® Exaggerated hypertensive response, tachycardia, or arrhythmias during physiologic stress or exposure to exogenous catecholamines Details Metoprolol Miglitol Glyset® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metoprolol Nabumetone Relafen Reduced antihypertensive effect Details Metoprolol Naproxen Aleve Reduced antihypertensive effect Details Metoprolol Nateglinide Starlix® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metoprolol Nifedipine Adalat® An increased risk of congestive heart failure, severe hypotension or exacerbation of angina Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.