Metoprolol

62 interactions 3 explained in plain English
Also sold as: Kapspargo Kapspargo Sprinkle® Lopressor Lopressor® Toprol Toprol® Toprol® XL
About Metoprolol

Metoprolol is a beta blocker used to treat high blood pressure, chest pain, and heart failure. Read the full Metoprolol drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Sertraline Albuterol Oral Inhalation Abiraterone Clonidine Transdermal Patch Olodaterol Oral Inhalation Lacosamide Injection
8 Major 53 Moderate 1 Minor
All (62) Major (8) Moderate (53) Minor (1)

Moderate

Metoprolol Acarbose Prandase® Explained Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metoprolol Asenapine Transdermal Patch Secuado An increased risk of hypotension Details Metoprolol Aspirin Acuprin® Reduced antihypertensive effect Details Metoprolol Aspirin Rectal Aspirin Reduced antihypertensive effect Details Metoprolol Alfuzosin UroXatral An exaggerated hypotensive response to the first dose of the alpha blocker Details Metoprolol Alogliptin Nesina Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metoprolol Bromfenac Ophthalmic Bromday® Reduced antihypertensive effect Details Metoprolol Canagliflozin Invokana Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metoprolol Dapagliflozin Farxiga Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metoprolol Diclofenac Ophthalmic Voltaren® Eye Drops Reduced antihypertensive effect Details Metoprolol Diclofenac Topical (Actinic Keratosis) Pennsaid Reduced antihypertensive effect Details Metoprolol Diclofenac Topical (Arthritis Pain) Pennsaid® Reduced antihypertensive effect Details Metoprolol Diclofenac Transdermal Patch Flector Reduced antihypertensive effect Details Metoprolol Digoxin Cardoxin® Increased risk of bradycardia and possible digitalis glycoside toxicity Details Metoprolol Doxazosin Cardura An exaggerated hypotensive response to the first dose of the alpha blocker Details Metoprolol Dulaglutide Injection Trulicity Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metoprolol Empagliflozin Glyxambi® (as a combination product containing Empagliflozin and Linagliptin) Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metoprolol Ertugliflozin Steglatro Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metoprolol Etodolac Lodine Reduced antihypertensive effect Details Metoprolol Exenatide Injection Bydureon Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metoprolol Fenoprofen Fenopron Reduced antihypertensive effect Details Metoprolol Flurbiprofen Ansaid Reduced antihypertensive effect Details Metoprolol Flurbiprofen Ophthalmic Ocufen Reduced antihypertensive effect Details Metoprolol Glimepiride Amaryl Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metoprolol Glipizide Glucotrol Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metoprolol Glucagon Injection Baqsimi A transient increase in pulse and blood pressure Details Metoprolol Glucagon Injection / Solution Baqsimi A transient increase in pulse and blood pressure Details Metoprolol Glucagon Nasal Powder Baqsimi A transient increase in pulse and blood pressure Details Metoprolol Hydralazine Apresoline® Increased metoprolol concentrations Details Metoprolol Ibuprofen Addaprin Reduced antihypertensive effect Details Metoprolol Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metoprolol Insulin Detemir (Rdna Origin) Injection Levemir Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metoprolol Insulin Glulisine (Rdna Origin) Injection Apidra Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metoprolol Ketoprofen Actron® Reduced antihypertensive effect Details Metoprolol Ketorolac Acular Reduced antihypertensive effect Details Metoprolol Ketorolac Injection Acular Reduced antihypertensive effect Details Metoprolol Ketorolac Nasal Spray Sprix Reduced antihypertensive effect Details Metoprolol Ketorolac Ophthalmic Acular Reduced antihypertensive effect Details Metoprolol Linagliptin Tradjenta Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metoprolol Liraglutide Injection Saxenda Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.