Metoprolol

Name: Metoprolol Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

62 interactions 3 explained in plain English

Also sold as: Kapspargo Kapspargo Sprinkle® Lopressor Lopressor® Toprol Toprol® Toprol® XL

About Metoprolol

Metoprolol is a beta blocker used to treat high blood pressure, chest pain, and heart failure. Read the full Metoprolol drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Sertraline Albuterol Oral Inhalation Abiraterone Clonidine Transdermal Patch Olodaterol Oral Inhalation Lacosamide Injection

8 Major 53 Moderate 1 Minor

All (62) Major (8) Moderate (53) Minor (1)

Major

Metoprolol Sertraline Explained Increased CYP2D6 substrate exposure Details Metoprolol Albuterol Oral Inhalation Accuneb® Explained Reduced efficacy of albuterol Details Metoprolol Abiraterone Abirtega Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse effects Details Metoprolol Clonidine Transdermal Patch Catapres An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Metoprolol Indacaterol Oral Inhalation Arcapta® Decreased efficacy of indacaterol Details Metoprolol Lacosamide Injection Motpoly An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Metoprolol Methylergonovine Methergine An increased risk of enhanced vasoconstrictive Details Metoprolol Olodaterol Oral Inhalation Striverdi Reduced olodaterol exposure and reduced beta-adrenergic blockers exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.