Metronidazole Vaginal

Name: Metronidazole Vaginal Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

242 interactions 832 cited references

Also sold as: MetroGel® Vaginal Nuvessa Nuvessa® Vandazole Vandazole®

About Metronidazole Vaginal

Metronidazole is used to treat vaginal infections such as bacterial vaginosis (an infection caused from too much of certain bacteria in the vagina). Metronidazole is in a class of medications called nitroimidazole antimicrobials. It works by stopping the growth of bacteria. Read the full Metronidazole Vaginal drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Pimozide Piperaquine Saquinavir Sparfloxacin Terfenadine Thioridazine

15 Contraindicated 214 Major 13 Moderate

All (242) Contraindicated (15) Major (214) Moderate (13)

Moderate

Metronidazole Vaginal Milk Thistle Reduced metronidazole and active metabolite exposure Details Metronidazole Vaginal Phenindione An increased risk of bleeding Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.