Metronidazole Vaginal

242 interactions 832 cited references

Also sold as: MetroGel® Vaginal Nuvessa Nuvessa® Vandazole Vandazole®

About Metronidazole Vaginal

Metronidazole is used to treat vaginal infections such as bacterial vaginosis (an infection caused from too much of certain bacteria in the vagina). Metronidazole is in a class of medications called nitroimidazole antimicrobials. It works by stopping the growth of bacteria. Read the full Metronidazole Vaginal drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Pimozide Piperaquine Saquinavir Sparfloxacin Terfenadine Thioridazine

15 Contraindicated 214 Major 13 Moderate

All (242) Contraindicated (15) Major (214) Moderate (13)

Major

Metronidazole Vaginal Tacrolimus Astagraf Increased risk of QT-interval prolongation and arrhythmia; increased serum tacrolimus concentration and toxicity Details Metronidazole Vaginal Taletrectinib Ibtrozi Increased risk of QT interval prolongation and torsade de pointes Details Metronidazole Vaginal Tamoxifen Nolvadex® An increased risk of QT interval prolongation Details Metronidazole Vaginal Tegafur Increased exposure of 5-fluorouracil Details Metronidazole Vaginal Telaprevir An increased risk of QT interval prolongation Details Metronidazole Vaginal Telavancin Vibativ An increased risk of QT interval prolongation Details Metronidazole Vaginal Telithromycin An increased risk of QT interval prolongation Details Metronidazole Vaginal Tetrabenazine Xenazine An increased risk of QT interval prolongation Details Metronidazole Vaginal Tolterodine Detrol An increased risk of QT interval prolongation Details Metronidazole Vaginal Toremifene Fareston An increased risk of QT interval prolongation Details Metronidazole Vaginal Tramadol ConZip An increased risk of seizure Details Metronidazole Vaginal Trazodone Raldesy An increased risk of QT interval prolongation Details Metronidazole Vaginal Triclabendazole Egaten An increased risk of QT interval prolongation Details Metronidazole Vaginal Trimipramine An increased risk of QT interval prolongation Details Metronidazole Vaginal Triptorelin Increased risk of QT interval prolongation Details Metronidazole Vaginal Vandetanib Caprelsa An increased risk of QT interval prolongation Details Metronidazole Vaginal Vardenafil Levitra An increased risk of QT interval prolongation Details Metronidazole Vaginal Vemurafenib Zelboraf An increased risk of QT interval prolongation Details Metronidazole Vaginal Venlafaxine An increased risk of QT interval prolongation Details Metronidazole Vaginal Vepdegestrant Veppanu An increased risk of QT interval prolongation and an increased risk of torsade de pointes, polymorphic ventricular tachycardia, ot... Details Metronidazole Vaginal Vilanterol An increased risk of QT interval prolongation Details Metronidazole Vaginal Vinflunine An increased risk of QT interval prolongation Details Metronidazole Vaginal Voclosporin Lupkynis An increased risk of QT interval prolongation Details Metronidazole Vaginal Voriconazole Vfend An increased risk of QT interval prolongation Details Metronidazole Vaginal Vorinostat Zolinza An increased risk of QT interval prolongation Details Metronidazole Vaginal Warfarin Coumadin Increased warfarin exposure and INR, and an increased risk of bleeding Details Metronidazole Vaginal Ziftomenib Komzifti An increased risk of QT interval prolongation and torsade de pointes Details Metronidazole Vaginal Zotepine An increased risk of QT interval prolongation Details Metronidazole Vaginal Zuclopenthixol An increased risk of QT interval prolongation Details

Moderate

Metronidazole Vaginal Anisindione An increased risk of bleeding Details Metronidazole Vaginal Carbamazepine Carbatrol Increased carbamazepine serum concentrations and potential carbamazepine toxicity Details Metronidazole Vaginal Cholestyramine Prevalite Decreased metronidazole effectiveness Details Metronidazole Vaginal Cyclosporine Atopica An increased risk of cycloSPORINE toxicity (nephrotoxicity, cholestasis, paresthesias) Details Metronidazole Vaginal Dicumarol An increased risk of bleeding Details Metronidazole Vaginal Dihydroergotamine Brekiya Increased plasma concentrations of ergot derivatives and increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Metronidazole Vaginal Ergoloid Mesylates Alkergot® Increased plasma concentrations of ergot derivatives and increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Metronidazole Vaginal Ergonovine Increased plasma concentrations of ergot derivatives and increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Metronidazole Vaginal Ergotamine Ergomar Increased plasma concentrations of ergot derivatives and increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Metronidazole Vaginal Lixisenatide Delayed therapeutic effect Details Metronidazole Vaginal Methylergonovine Methergine Increased plasma concentrations of ergot derivatives and increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.