Midazolam Nasal Spray

276 interactions 915 cited references

Also sold as: Nayzilam Nayzilam®

About Midazolam Nasal Spray

Midazolam nasal spray is used for emergency situations to stop cluster seizures (episodes of increased seizure activity) in adults and children 12 years of age and older who are taking other medications to treat epilepsy (seizures). Midazolam is in a class of medications called benzodiazepines. It works by calming abno… Read the full Midazolam Nasal Spray drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ritonavir Saquinavir Telaprevir Tipranavir Amprenavir Atazanavir

22 Contraindicated 197 Major 52 Moderate 5 Minor

All (276) Contraindicated (22) Major (197) Moderate (52) Minor (5)

Major

Midazolam Nasal Spray Tapentadol Nucynta An increased risk of CNS depression and an increased risk of respiratory depression, profound sedation, coma and death. Details Midazolam Nasal Spray Tazemetostat Tazverik Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Midazolam Nasal Spray Temazepam Restoril Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Thiopental Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Thioridazine Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Tilidine Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Tizanidine Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Topiramate Eprontia Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Tramadol ConZip Increased risk of CNS depression Details Midazolam Nasal Spray Tranylcypromine Parnate An increased risk of CNS depression Details Midazolam Nasal Spray Trazodone Raldesy Increased risk of CNS depression Details Midazolam Nasal Spray Triazolam Halcion Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Trofinetide Daybue Increased CYP3A substrate exposure and an increased risk of CYP3A substrate-related toxicities Details Midazolam Nasal Spray Voriconazole Vfend Increase midazolam exposure and potential midazolam toxicity (excessive sedation and prolonged hypnotic effects) Details Midazolam Nasal Spray Zaleplon Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Ziprasidone Geodon An increased risk of CNS depression Details Midazolam Nasal Spray Zolpidem Ambien An increased risk of CNS depression, complex sleep behaviors and respiratory depression Details Midazolam Nasal Spray Zopiclone Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Zuranolone Zurzuvae An increased risk of CNS depression Details

Moderate

Midazolam Nasal Spray Aprepitant Aponvie Increased midazolam exposure Details Midazolam Nasal Spray Armodafinil Nuvigil Decreased midazolam effectiveness Details Midazolam Nasal Spray Artemether Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Midazolam Nasal Spray Brimonidine Alphagan An increased risk of CNS depression Details Midazolam Nasal Spray Carbachol Isopto Carbachol An increased risk of CNS depression Details Midazolam Nasal Spray Cimetidine Tagamet Midazolam toxicity (CNS depression, sedation, dizziness, ataxia, weakness, decreased cognition or motor performance) Details Midazolam Nasal Spray Clonidine Duraclon An increased risk of sedation and somnolence Details Midazolam Nasal Spray Crizotinib Xalkori Increased midazolam exposure Details Midazolam Nasal Spray Cyclosporine Atopica Decreased midazolam clearance and increased midazolam plasma concentrations Details Midazolam Nasal Spray Dalfopristin An increased risk of midazolam toxicity (excessive sedation, confusion) Details Midazolam Nasal Spray Dong Quai Excessive muscle relaxation and central nervous system depression Details Midazolam Nasal Spray Echinacea Alterations in midazolam effectiveness Details Midazolam Nasal Spray Fluvoxamine Elevated serum midazolam concentrations Details Midazolam Nasal Spray Folic Acid Folacin Reduced folic acid exposure and reduced efficacy of folic acid Details Midazolam Nasal Spray Fosaprepitant Emend Injection Increased midazolam exposure Details Midazolam Nasal Spray Fosphenytoin Cerebyx Decreased efficacy of midazolam Details Midazolam Nasal Spray Ganaxolone Ztalmy An increased risk of somnolence and sedation Details Midazolam Nasal Spray Ginkgo Increased or decreased midazolam plasma concentrations Details Midazolam Nasal Spray Goldenseal Increased plasma concentrations of midazolam Details Midazolam Nasal Spray Haloperidol An increased risk of CNS depression Details Midazolam Nasal Spray Halothane Potentiation of anesthetic effects of halothane Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.