Midazolam Nasal Spray

276 interactions 915 cited references
Also sold as: Nayzilam Nayzilam®
About Midazolam Nasal Spray

Midazolam nasal spray is used for emergency situations to stop cluster seizures (episodes of increased seizure activity) in adults and children 12 years of age and older who are taking other medications to treat epilepsy (seizures). Midazolam is in a class of medications called benzodiazepines. It works by calming abno… Read the full Midazolam Nasal Spray drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ritonavir Saquinavir Telaprevir Tipranavir Amprenavir Atazanavir
22 Contraindicated 197 Major 52 Moderate 5 Minor
All (276) Contraindicated (22) Major (197) Moderate (52) Minor (5)

Moderate

Midazolam Nasal Spray Hydrastis Increased plasma concentrations of midazolam Details Midazolam Nasal Spray Josamycin Increased benzodiazepine toxicity (CNS depression, ataxia, lethargy) Details Midazolam Nasal Spray Kava Increased central nervous system depression Details Midazolam Nasal Spray Laropiprant Increased exposure of active metabolite of midazolam Details Midazolam Nasal Spray Mavacamten Camzyos Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Midazolam Nasal Spray Mitotane Lysodren Decreased midazolam exposure Details Midazolam Nasal Spray Omeprazole Gastrobim Benzodiazepine toxicity (CNS depression, ataxia, lethargy) Details Midazolam Nasal Spray Paclitaxel Abraxane Altered (increased/reduced) PACLitaxel exposure, reduced PACLitaxel exposure and an increased PACLitaxel-related adverse reactions... Details Midazolam Nasal Spray Paclitaxel Protein-Bound Altered (increased/reduced) PACLitaxel exposure, reduced PACLitaxel exposure and an increased PACLitaxel-related adverse reactions... Details Midazolam Nasal Spray Passionflower Additive CNS depression Details Midazolam Nasal Spray Pazopanib Votrient Increased midazolam plasma concentrations Details Midazolam Nasal Spray Phenytoin Dilantin Decreased efficacy of midazolam Details Midazolam Nasal Spray Pioglitazone Actos Decreased plasma concentrations of midazolam Details Midazolam Nasal Spray Quinupristin An increased risk of midazolam toxicity (excessive sedation, confusion) Details Midazolam Nasal Spray Ranitidine Increased midazolam bioavailability Details Midazolam Nasal Spray Rifampin Rifadin Decreased plasma concentrations of midazolam Details Midazolam Nasal Spray Rifapentine Priftin Reduced diazepam plasma concentrations and effectiveness Details Midazolam Nasal Spray Rilzabrutinib Wayrilz Increased CYP3A substrate exposure and an increased risk of CYP3A substrate-related adverse reactions Details Midazolam Nasal Spray Roxithromycin Increased benzodiazepine toxicity (CNS depression, ataxia, lethargy) Details Midazolam Nasal Spray Sevoflurane Petrem Reduced sevoflurane (MAC) exposure needed to produce anesthesia and an increased risk of respiratory depression Details Midazolam Nasal Spray St John's Wort Reduced benzodiazepine effectiveness Details Midazolam Nasal Spray Suvorexant Belsomra Additive sedative effects Details Midazolam Nasal Spray Tecovirimat Reduced efficacy of midazolam Details Midazolam Nasal Spray Teduglutide Increased exposure of orally administered benzodiazepines Details Midazolam Nasal Spray Telithromycin Increased risk for benzodiazepine toxicity (CNS depression, sedation, dizziness, ataxia, weakness, decreased cognition or motor pe... Details Midazolam Nasal Spray Thalidomide Thalomid Increased midazolam metabolism and clearance Details Midazolam Nasal Spray Theophylline Accurbron® Decreased benzodiazepine effectiveness Details Midazolam Nasal Spray Troleandomycin Increased benzodiazepine toxicity (CNS depression, ataxia, lethargy) Details Midazolam Nasal Spray Valerian Additive CNS depression or reduced effectiveness of the benzodiazepine Details Midazolam Nasal Spray Verapamil Calan Increased/prolonged sedation Details Midazolam Nasal Spray Xanomeline Increased oral sensitive CYP3A4 substrate exposure and an increased risk on severity and frequency of sensitive CYP3A4 substrate-r... Details

Minor

Midazolam Nasal Spray Atorvastatin Atorvaliq Prolonged midazolam efficacy Details Midazolam Nasal Spray Magnolia Increased central nervous system depression Details Midazolam Nasal Spray Probenecid Enhanced CNS depressive effects of midazolam Details Midazolam Nasal Spray Skullcap Increased central nervous system depression Details Midazolam Nasal Spray Tan-Shen Increased risk of central nervous system depression Details

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