Mifepristone and Lovastatin: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Mifepristone
Lovastatin
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased lovastatin exposure and an increased risk of lovastatin-related adverse effects, such as, myopathy and rhabdomyolysis
Interaction Deep Dive
The coadministration of miFEPRIStone with lovastatin is contraindicated due to a risk of increased lovastatin exposure and serious side effects, such as myopathy and rhabdomyolysis. Although not specifically studied with lovastatin, the coadministration of simvastatin (another CYP3A substrate) with miFEPRIStone resulted in an AUC mean ratio (with/without) of 10.4 and 15.7 for simvastatin and simvastatin acid, respectively, compared with simvastatin exposure alone. Due to the long terminal half-life of miFEPRIStone at steady state, at least 2 weeks should pass after stopping miFEPRIStone before initiating lovastatin2. If treatment with miFEPRIStone is unavoidable, suspend lovastatin during the course of miFEPRIStone treatment 1.
Why it happens (mechanism)
Inhibition of CYP3A4-mediated metabolism of lovastatin
Literature reports
2 reports — tap to read
a) Although not specifically studied with lovastatin, the coadministration of simvastatin (another CYP3A substrate) with miFEPRIStone resulted in an AUC mean ratio (with/without) of 10.4 and 15.7 for simvastatin and simvastatin acid, respectively, compared with simvastatin exposure alone. Due to the long terminal half-life of miFEPRIStone at steady state, at least 2 weeks should pass after stopping miFEPRIStone before initiating lovastatin 2.
b) In a drug interaction study, coadministration of itraconazole (strong CYP3A4 inhibitor) and lovastatin increased lovastatin AUC and Cmax by 14.8-fold and 14.5-fold, respectively 1.
Common questions
Can I take Mifepristone and Lovastatin together?
Increased lovastatin exposure and an increased risk of lovastatin-related adverse effects, such as, myopathy and rhabdomyolysis Always confirm with your pharmacist or prescriber before making any change.
How serious is the Mifepristone and Lovastatin interaction?
It is rated contraindicated. These should generally not be used together.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Mifepristone or Lovastatin need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (2)
- Product Information: ALTOPREV(R) oral extended-release tablets, lovastatin oral extended-release tablets. Covis Pharma (per FDA), King of Prussia, PA, 2024. DailyMed
- Product Information: KORLYM(R) oral tablets, mifepristone oral tablets. Corcept Therapeutics Incorporated (per Dailmed), Redwood City, CA, 2024. DailyMed
Keep reading about Mifepristone
Keep reading about Lovastatin
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Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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