Morphine Injection

437 interactions 767 cited references
Also sold as: Astramorph® PF Duramorph Duramorph® Infumorph Infumorph® Kadian Mitigo MS Contin
About Morphine Injection

Morphine injection is used to relieve moderate to severe pain. Morphine is in a class of medications called opiate (narcotic) analgesics. It works by changing the way the brain and nervous system respond to pain. Read the full Morphine Injection drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Morphine Injection Thiopropazate Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Thioridazine Increased risk of urinary retention, severe constipation, and paralytic ileus and an increased risk of profound sedation, respirat... Details Morphine Injection Thiothixene Increased risk of urinary retention, severe constipation, and paralytic ileus Details Morphine Injection Tianeptine Increased risk of serotonin syndrome Details Morphine Injection Ticagrelor Brilinta Increased morphine exposure and reduced absorption of ticagrelor Details Morphine Injection Tilidine Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Morphine Injection Tiotropium Increased risk of urinary retention, severe constipation, and paralytic ileus Details Morphine Injection Tizanidine Increased risk of urinary retention, severe constipation, and paralytic ileus, an increased risk of profound sedation, hypotension... Details Morphine Injection Tolonium Chloride Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Tolterodine Detrol Increased risk of urinary retention, severe constipation, and paralytic ileus Details Morphine Injection Tolvaptan Jynarque Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Topiramate Eprontia Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Torsemide Soaanz Reduced efficacy of diuretics Details Morphine Injection Tramadol ConZip Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Morphine Injection Trazodone Raldesy Increased risk of serotonin syndrome and an increased risk of CNS depression Details Morphine Injection Triamterene Dyrenium Reduced efficacy of diuretics Details Morphine Injection Triazolam Halcion Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Trichlormethiazide Reduced efficacy of diuretics Details Morphine Injection Trifluoperazine Increased risk of urinary retention, severe constipation, and paralytic ileus and an increased risk of profound sedation, respirat... Details Morphine Injection Trifluperidol Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Triflupromazine Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Trihexyphenidyl Increased risk of urinary retention, severe constipation, and paralytic ileus Details Morphine Injection Trimeprazine Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Trimipramine Increased risk of urinary retention, severe constipation, paralytic ileus and an increased risk of serotonin syndrome Details Morphine Injection Tropicamide Mydriacyl Increased risk of urinary retention, severe constipation, and paralytic ileus Details Morphine Injection Trospium Increased morphine exposure, increased trospium exposure and an increased risk of urinary retention, constipation and paralytic il... Details Morphine Injection Tryptophan Increased risk of serotonin syndrome Details Morphine Injection Tucatinib Tukysa Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Umeclidinium Increased risk of urinary retention, severe constipation, and paralytic ileus Details Morphine Injection Vandetanib Caprelsa Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Velpatasvir Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Vemurafenib Zelboraf Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Venetoclax Venclexta Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Venlafaxine Increased risk of serotonin syndrome Details Morphine Injection Verapamil Calan Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Vibegron Gemtesa Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Vilazodone Viibryd Increased morphine exposure, increased risk of morphine-related adverse effects (hypotension, respiratory depression, profound sed... Details Morphine Injection Voclosporin Lupkynis Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Vorapaxar Zontivity Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Vortioxetine Trintellix Increased risk of serotonin syndrome Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.