Nepafenac
91 interactions 5 explained in plain English
Also sold as:
Ilevro
Nevanac
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Ketorolac Injection
Ketorolac Nasal Spray
Ketorolac
Ketorolac Ophthalmic
Diclofenac Ophthalmic
Epoprostenol
Major
Nepafenac Fondaparinux Injection Arixtra An increased risk of bleeding Details Nepafenac Furosemide Injection Disal Reduced diuretic effectiveness and possible nephrotoxicity Details Nepafenac Heparin An increased risk of bleeding Details Nepafenac Heparin Injection Lipo-Hepin® An increased risk of bleeding Details Nepafenac Hydrocortisone Ala-Cort Increased risk of gastrointestinal ulcer or bleeding Details Nepafenac Hydrocortisone Injection A-Hydrocort® Increased risk of gastrointestinal ulcer or bleeding Details Nepafenac Ibuprofen Addaprin An increased risk of gastrointestinal toxicity Details Nepafenac Iloprost Aurlumyn An increased risk of bleeding Details Nepafenac Ketoprofen Actron® Increased risk of bleeding Details Nepafenac Lithium Carbonate Lithobid Increased lithium exposure and an increased risk of lithium toxicity Details Nepafenac Meclofenamate Meclodium® Increased risk of bleeding Details Nepafenac Mefenamic Acid Ponstel® Increased risk of bleeding Details Nepafenac Meloxicam Alloxate An increased risk of gastrointestinal toxicity and an increased risk of bleeding Details Nepafenac Meloxicam Injection Alloxate An increased risk of gastrointestinal toxicity and an increased risk of bleeding Details Nepafenac Melphalan Alkeran An increased risk of bleeding Details Nepafenac Melphalan Injection Alkeran An increased risk of bleeding Details Nepafenac Mesalamine Apriso Increased risk of bleeding Details Nepafenac Mesalamine Rectal Canasa Increased risk of bleeding Details Nepafenac Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Nepafenac Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Nepafenac Nabumetone Relafen Increased risk of bleeding Details Nepafenac Naproxen Aleve Increased risk of bleeding Details Nepafenac Pemetrexed Injection Alimta Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... DetailsModerate
Nepafenac Lisinopril Prinivil Explained Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Nepafenac Atenolol Tenormin Explained Reduced antihypertensive effect Details Nepafenac Acebutolol Sectral® Reduced antihypertensive effect Details Nepafenac Benazepril Lotensin Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Nepafenac Azilsartan Edarbi Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Nepafenac Betaxolol Betoptic S Reduced antihypertensive effect Details Nepafenac Betaxolol Ophthalmic Betoptic® Reduced antihypertensive effect Details Nepafenac Bisoprolol Zebeta® Reduced antihypertensive effect Details Nepafenac Captopril Capoten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Nepafenac Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia Details Nepafenac Enalapril Epaned Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Nepafenac Eprosartan Teveten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Nepafenac Esmolol Brevibloc Reduced antihypertensive effect Details Nepafenac Fosinopril Monopril® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Nepafenac Irbesartan Avapro Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Nepafenac Labetalol Normodyne® Reduced antihypertensive effect Details Nepafenac Levobunolol Ophthalmic AKBeta® Reduced antihypertensive effect DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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