Omeprazole and Paritaprevir: Interaction Details
AI-assisted, pharmacist-reviewed · AI content regenerated Jul 11, 2026 · Source data updated Jul 2, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Paritaprevir
No brand names on recordOmeprazole
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
Here's what's going on. When omeprazole (your acid-reducing medicine, like Prilosec) is taken with paritaprevir (part of your hepatitis C treatment), two things can happen at once. The paritaprevir level in your blood can go up, which could mean more side effects. At the same time, the omeprazole level can go down, so your heartburn or reflux may not be controlled as well.
The good news is this is very manageable. Your care team can watch how you feel and adjust the omeprazole dose if your stomach symptoms come back, and keep an eye on you for any paritaprevir side effects. Please don't change anything on your own. Just check with your pharmacist or doctor.
Effect: Increased paritaprevir plasma exposure and decreased omeprazole exposure with concurrent use. Neither agent is a prodrug in a way that reverses this; both are affected directly.
- Direction: Paritaprevir up (more adverse events), omeprazole down (possible loss of acid suppression).
- Mechanism: Unknown/unspecified.
- Onset: Unspecified. Evidence: Theoretical.
- Management: Monitor for reduced omeprazole efficacy; a dose increase may be considered if symptoms are poorly controlled, but avoid omeprazole doses greater than 40 mg/day. Monitor for paritaprevir-associated adverse events.
Severity on file: major, though substantiation is theoretical.
What happens
Increased paritaprevir exposure; decreased omeprazole exposure
Interaction Deep Dive
Taking omeprazole together with paritaprevir can raise paritaprevir plasma levels, while omeprazole concentrations may drop. Watch for reduced omeprazole effectiveness, and in patients whose symptoms remain poorly controlled, consider raising the dose. Do not use omeprazole at doses above 40 mg/day1. Also monitor for an increase in adverse events linked to paritaprevir.
Why it happens (mechanism)
Unknown
How to manage this interaction
How your care team handles this:
- Keep taking both medicines exactly as prescribed unless told otherwise.
- Your team may watch whether your reflux or heartburn symptoms stay controlled, since omeprazole levels can drop.
- If your stomach symptoms return, your omeprazole dose may be adjusted and individualized by your care team, but generally not above 40 mg per day.
- They may also monitor you more closely for paritaprevir side effects, since its levels can rise.
What to raise: Tell your pharmacist or prescriber if your heartburn comes back or if you notice new or worsening side effects.
Management is individual — confirm any change with your pharmacist or prescriber.
Common questions
Can I take Omeprazole and Paritaprevir together?
Taking omeprazole with paritaprevir can raise paritaprevir levels (more side effects) and lower omeprazole levels (less heartburn relief); keep both as prescribed, stay at or below 40 mg/day of omeprazole, and tell your care team if symptoms return. Always confirm with your pharmacist or prescriber before making any change.
How serious is the Omeprazole and Paritaprevir interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How is the Omeprazole and Paritaprevir interaction managed?
How your care team handles this: Keep taking both medicines exactly as prescribed unless told otherwise. Your team may watch whether your reflux or heartburn symptoms stay controlled, since omeprazole levels can drop. If your stomach symptoms return, your omeprazole dose may be adjusted and individualized by your care team, but generally not above 40 mg per day. They may also monitor you more clos… Management is individual — always follow your own care team's guidance.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Omeprazole or Paritaprevir need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: VIEKIRA PAK oral tablets, ombitasvir paritaprevir ritonavir oral tablets and dasabuvir oral tablets. AbbVie Inc. (per manufacturer), North Chicago, Il, 2014.
Keep reading about Paritaprevir
Keep reading about Omeprazole
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Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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