Omeprazole and Relacorilant: Interaction Details
AI-assisted, pharmacist-reviewed · AI content regenerated Jul 11, 2026 · Source data updated Jul 2, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Relacorilant
Omeprazole
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
Here's what's going on. Relacorilant can slow down a liver enzyme called CYP3A4. That enzyme is one of the pathways your body uses to break down omeprazole (Prilosec). When it's slowed, omeprazole can build up in your body a bit more than usual, which can raise the chance of side effects.
The good news is that this is very manageable. Please don't stop or change either medicine on your own. Just let your pharmacist or doctor know you're taking both, and they can adjust the dose if needed and keep a closer eye on how you're doing.
Mechanism: Relacorilant inhibits CYP3A4-mediated metabolism. Omeprazole is partially a CYP3A4 substrate (also CYP2C19), so co-administration may increase omeprazole exposure (AUC/Cmax) and the risk of substrate-related adverse effects.
- Direction: Increased omeprazole exposure (inhibition; neither drug's clinical effect depends on prodrug activation here).
- Severity/evidence: Major; probable substantiation.
- Onset: Unspecified.
- Management: Manufacturer guidance is to avoid concomitant use with CYP3A4 substrates unless otherwise recommended. If used together, individualize dosing and monitor more closely for substrate-related adverse effects.
What happens
Increased CYP3A4 substrate exposure and an increased risk of CYP3A4-substrate-related adverse reactions
Interaction Deep Dive
Unless there is a specific recommendation to do otherwise, relacorilant should not be given together with CYP3A4 substrates. When used together, the exposure to these substrates may rise, along with an increased likelihood of adverse reactions associated with them1.
Why it happens (mechanism)
Inhibition of CYP3A4-mediated metabolism of relacorilant
How to manage this interaction
What your care team may do:
- Follow the labeling, which advises avoiding this combination unless your prescriber specifically recommends it.
- If both are needed, your team may adjust and individualize the omeprazole dose and monitor you more closely for side effects.
What you can do:
- Keep taking both exactly as prescribed unless told otherwise.
- Tell your pharmacist and prescriber you take both, and mention any new or stronger side effects so they can tailor your treatment.
Management is individual — confirm any change with your pharmacist or prescriber.
Literature reports
1 report — tap to read
a) In drug interaction studies, giving relacorilant 350 mg in the fasted state (1.8 times the relacorilant exposure achieved at the recommended dose) once daily over 10 days together with midazolam (a CYP3A4 substrate) raised Cmax by 3.1-fold and AUC by 8.9-fold 1.
Common questions
Can I take Omeprazole and Relacorilant together?
Relacorilant can raise omeprazole levels by slowing its breakdown, so this combination is generally avoided unless your prescriber recommends it; if you take both, your care team can adjust the dose and watch you more closely. Always confirm with your pharmacist or prescriber before making any change.
How serious is the Omeprazole and Relacorilant interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How is the Omeprazole and Relacorilant interaction managed?
What your care team may do: Follow the labeling, which advises avoiding this combination unless your prescriber specifically recommends it. If both are needed, your team may adjust and individualize the omeprazole dose and monitor you more closely for side effects. What you can do: Keep taking both exactly as prescribed unless told otherwise. Tell your pharmacist and prescriber you take both, and… Management is individual — always follow your own care team's guidance.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Omeprazole or Relacorilant need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: LIFYORLI™ oral capsules, relacorilant oral capsules. Corcept Therapeutics Incorporated (Per Manufacturer), Redwood City, CA, 2026. DailyMed
Keep reading about Relacorilant
Keep reading about Omeprazole
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Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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