Oxandrolone

20 interactions 107 cited references
Also sold as: Oxandrin Oxandrin®
About Oxandrolone

Oxandrolone is used with a diet program to cause weight gain in people who have lost too much weight due to surgery, injury, chronic (long-lasting) infections, trauma, or who are underweight for unknown reasons. Oxandrolone is also used to treat bone pain in people with osteoporosis (a condition in which the bones beco… Read the full Oxandrolone drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Deuruxolitinib Celecoxib Levoketoconazole Warfarin Bupropion Dicumarol
1 Contraindicated 17 Major 2 Moderate
All (20) Contraindicated (1) Major (17) Moderate (2)

Contraindicated

Oxandrolone Deuruxolitinib Increased deuruxolitinib exposure and an increased risk of deuruxolitinib-related adverse effects such as thrombosis Details

Major

Oxandrolone Azathioprine Azasan An increased risk of hepatotoxicity Details Oxandrolone Erdafitinib Balversa Increased erdafitinib exposure Details Oxandrolone Meloxicam Alloxate Increased meloxicam exposure and reduced meloxicam metabolic clearance Details Oxandrolone Meloxicam Injection Alloxate Increased meloxicam exposure and reduced meloxicam metabolic clearance Details Oxandrolone Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Oxandrolone Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Oxandrolone Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Oxandrolone Anisindione Increased risk of bleeding Details Oxandrolone Bupropion Aplenzin Lowering of the seizure threshold Details Oxandrolone Celecoxib Celebrex Increased celecoxib exposure Details Oxandrolone Dicumarol Increased anticoagulant response and increased risk of bleeding Details Oxandrolone Levoketoconazole Recorlev Increased risk of serious hepatotoxicity and drug-induced liver injury Details Oxandrolone Methadone Diskets Increased methadone exposure and an increased risk of opioid adverse effects Details Oxandrolone Pexidartinib Turalio Hepatotoxicity Details Oxandrolone Phenprocoumon Increased anticoagulant response and increased risk of bleeding Details Oxandrolone Voriconazole Vfend Increased voriconazole exposure Details Oxandrolone Warfarin Coumadin Increased warfarin exposure, increased INR, increased anticoagulant response and increased risk of bleeding Details

Moderate

Oxandrolone Glimepiride Amaryl Increased blood glucose lowering effect and increased risk of hypoglycemia Details Oxandrolone Nateglinide Starlix® Increased risk of hypoglycemia Details

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