Drug Interaction Report

Prasugrel and Morphine Injection: Interaction Details

A pharmacist-reviewed analysis of the Prasugrel and Morphine Injection interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Morphine Injection

Astramorph® PF Duramorph Duramorph® Infumorph Infumorph® Kadian Mitigo MS Contin
+

Prasugrel

Effient Effient®
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Aug 8, 2026
Editorial policy · Data sources
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Interaction severity
Major
Potentially serious — often needs a change or close monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 49 documented Prasugrel interactions, 44 are rated major — including this one.
Worried about symptoms right now? Contact your pharmacist or prescriber, or call Poison Control at 1-800-222-1222 (US). Call 911 for an emergency.
Onset
unspecified
Evidence
theoretical
Severity
Major

What happens

Reduced prasugrel exposure, reduced efficacy of prasugrel and delayed onset of antiplatelet effect

Interaction Deep Dive

Coadministration of intravenous morphine and prasugrel (oral P2Y12 inhibitor) can reduce the absorption and peak concentration of prasugrel and delay the onset of the antiplatelet effect. Consider the use of parenteral antiplatelet agent in the setting of acute coronary syndrome requiring coadministration of intravenous morphine3214.

Why it happens (mechanism)

Unknown

Common questions

Can I take Prasugrel and Morphine Injection together?

Reduced prasugrel exposure, reduced efficacy of prasugrel and delayed onset of antiplatelet effect Always confirm with your pharmacist or prescriber before making any change.

How serious is the Prasugrel and Morphine Injection interaction?

It is rated major. Potentially serious — often needs a change or close monitoring.

How quickly could this interaction happen?

The documented onset is "unspecified". The timing of this interaction is not well characterized.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

From our Q&A

Real reader questions about these medications, each personally answered by our pharmacist:

Questions for your pharmacist

  • Does my dose of Prasugrel or Morphine Injection need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there a safer alternative to one of these medications for me?

References (4)

  1. Product Information: INFUMORPH intrathecal, epidural injection, morphine sulfate intrathecal, epidural injection. Hikma Pharmaceuticals USA Inc (per FDA), Berkeley Heights, NJ, 2023. DailyMed
  2. Product Information: Morphine sulfate intramuscular, intravenous injection, morphine sulfate intramuscular, intravenous injection. Freenius Kabi. (per FDA), Lake Zurich, IL, 2023.
  3. Product Information: DURAMORPH intravenous, epidural, intrathecal injection, morphine sulfate intravenous, epidural, intrathecal injection. Hikma Pharmaceuticals USA Inc (Per FDA), Berkeley, NJ, 2023. DailyMed
  4. Product Information: Morphine sulfate intravenous injection, morphine sulfate intravenous injection. Mallinckrodt Inc (Per FDA), St. Louis, MO, 2023. DailyMed
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Morphine Injection

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All Morphine Injection interactions (437) Morphine Injection drug information
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Prasugrel

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All Prasugrel interactions (49) Prasugrel drug information
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This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.