Prazepam

22 interactions 2 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Midazolam Nasal Spray Nalbuphine Injection Fentanyl Transdermal Patch Butorphanol Injection Butorphanol Nasal Spray Lacosamide Injection
21 Major 1 Moderate
All (22) Major (21) Moderate (1)

Major

Prazepam Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of hypotension, respiratory depression, profound sedation, coma, and death Details Prazepam Buprenorphine Belbuca Explained An increased risk of CNS depression and respiratory depression Details Prazepam Aripiprazole Injection Abilify An increased risk of sedation and orthostatic hypotension Details Prazepam Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Prazepam Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Prazepam Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Prazepam Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Prazepam Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Prazepam Diazepam Rectal Diastat Increased risk of CNS depression Details Prazepam Esketamine Nasal Spray Spravato Increased risk of sedation Details Prazepam Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Prazepam Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Prazepam Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Prazepam Lacosamide Injection Motpoly An increased risk of CNS depression Details Prazepam Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Prazepam Metoclopramide Injection Gimoti Increased risk of CNS depression Details Prazepam Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Prazepam Midazolam Nasal Spray Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Prazepam Midazolam Injection Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Prazepam Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Prazepam Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression Details

Moderate

Prazepam Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.