Rifampin and Daprodustat: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Rifampin
Daprodustat
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Reduced daprodustat exposure and reduced efficacy of daprodustat
Interaction Deep Dive
Concomitant administration of daprodustat with moderate CYP2C8 inducers may decrease daprodustat exposure, which may result in loss of daprodustat efficacy. Monitor hemoglobin and adjust the dose of daprodustat when initiating or stopping therapy with CYP2C8 inducers during treatment with daprodustat1.
Why it happens (mechanism)
Induction of CYP2C8-mediated metabolism of daprodustat
Common questions
Can I take Rifampin and Daprodustat together?
Reduced daprodustat exposure and reduced efficacy of daprodustat Always confirm with your pharmacist or prescriber before making any change.
How serious is the Rifampin and Daprodustat interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Rifampin or Daprodustat need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: JESDUVROQ oral tablets, daprodustat oral tablets. GlaxoSmithKline (per FDA), Durham, NC, 2023. DailyMed
Keep reading about Rifampin
Keep reading about Daprodustat
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Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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