Rifampin and Eravacycline Injection: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Rifampin
Eravacycline Injection
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Reduced eravacycline concentrations and efficacy
Interaction Deep Dive
Concomitant use of eravacycline, a CYP3A substrate, and rifampin, a strong CYP3A inducer, resulted in a 35% decrease in eravacycline AUC and a 54% increase in clearance. When used concomitantly with strong CYP3A inducers, increase the eravacycline dose to 1.5 mg/kg IV every 12 hours1.
Why it happens (mechanism)
Induction of CYP3A-mediated eravacycline metabolism
Literature reports
1 report — tap to read
a) When eravacycline was administered concomitantly with rifampin, a strong CYP3A inducer, eravacycline AUC decreased by 35% and clearance increased by 54% 1.
Common questions
Can I take Rifampin and Eravacycline Injection together?
Reduced eravacycline concentrations and efficacy Always confirm with your pharmacist or prescriber before making any change.
How serious is the Rifampin and Eravacycline Injection interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Rifampin or Eravacycline Injection need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: XERAVA(TM) intravenous injection, eravacycline intravenous injection. Tetraphase Pharmaceuticals Inc (per FDA), Watertown, MA, 2018. DailyMed
Keep reading about Rifampin
Keep reading about Eravacycline Injection
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Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
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