Scopolamine and Butorphanol Injection: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Scopolamine
Butorphanol Injection
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased or potentiated scopolamine effects and an increased risk of CNS depression
Interaction Deep Dive
Concomitant use of scopolamine with other drugs that cause CNS adverse reactions of drowsiness, dizziness, or disorientation (eg, sedatives, hypnotics, opiates, anxiolytics) may potentiate the effects of scopolamine. Choose either scopolamine or CNS depressant, depending on the importance of the drug to the patient. If the coadministration cannot be avoided, monitor patients for CNS adverse reactions1.
Why it happens (mechanism)
Additive CNS depression
Common questions
Can I take Scopolamine and Butorphanol Injection together?
Increased or potentiated scopolamine effects and an increased risk of CNS depression Always confirm with your pharmacist or prescriber before making any change.
How serious is the Scopolamine and Butorphanol Injection interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Scopolamine or Butorphanol Injection need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: TRANSDERM SCOP transdermal system patch, scopolamine transdermal system patch. Baxter Healthcare Corporation (per FDA), Deerfield, IL, 2025. DailyMed
Keep reading about Scopolamine
Keep reading about Butorphanol Injection
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