Scopolamine

32 interactions 4 explained in plain English
Also sold as: Pamine
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Scopolamine Acetaminophen And Codeine Capital® & Codeine Explained Increased or potentiated scopolamine effects, an increased risk of CNS depression and an increased risk of paralytic ileus Details Scopolamine Amitriptyline Elavil Explained Increased or potentiated scopolamine effects, an increased risk of CNS depression and an increased risk of intestinal obstruction,... Details Scopolamine Buprenorphine Belbuca Explained Increased or potentiated scopolamine effects, an increased risk of CNS depression and an increased risk of paralytic ileus Details Scopolamine Trospium / Xanomeline Cobenfy Explained Increased or potentiated scopolamine effects, an increased risk of CNS adverse reactions and an increased risk of intestinal obstr... Details Scopolamine Aripiprazole Injection Abilify Increased or potentiated scopolamine effects and an increased risk of CNS depression Details Scopolamine Asenapine Transdermal Patch Secuado Increased or potentiated scopolamine effects and an increased risk of CNS depression Details Scopolamine Aclidinium Oral Inhalation Tudorza Increased or potentiated scopolamine effects, an increased risk of CNS adverse reactions and an increased risk of intestinal obstr... Details Scopolamine Atropine Ophthalmic Atropine Care 1% Increased or potentiated scopolamine effects, an increased risk of CNS adverse reactions and an increased risk of intestinal obstr... Details Scopolamine Butorphanol Injection Butorphic Increased or potentiated scopolamine effects and an increased risk of CNS depression Details Scopolamine Butorphanol Nasal Spray Stadol® NS Increased or potentiated scopolamine effects and an increased risk of CNS depression Details Scopolamine Cetirizine Injection Aller-Tec Increased or potentiated scopolamine effects and an increased risk of CNS depression Details Scopolamine Cetirizine Ophthalmic Zerviate Increased or potentiated scopolamine effects and an increased risk of CNS depression Details Scopolamine Cyclopentolate Ophthalmic Akpentolate® Increased or potentiated scopolamine effects, an increased risk of CNS adverse reactions and an increased risk of intestinal obstr... Details Scopolamine Diazepam Nasal Spray Valtoco Increased or potentiated scopolamine effects and an increased risk of CNS depression Details Scopolamine Diazepam Rectal Diastat Increased or potentiated scopolamine effects and an increased risk of CNS depression Details Scopolamine Diphenhydramine Injection Banophen Increased or potentiated scopolamine effects, an increased risk of CNS depression and an increased risk of intestinal obstruction,... Details Scopolamine Diphenhydramine Topical Afterbite with Antihistamine Increased or potentiated scopolamine effects, an increased risk of CNS depression and an increased risk of intestinal obstruction,... Details Scopolamine Esketamine Nasal Spray Spravato Increased or potentiated scopolamine effects and an increased risk of CNS depression Details Scopolamine Fentanyl Transdermal Patch Duragesic® Increased or potentiated scopolamine effects, an increased risk of CNS depression and an increased risk of urinary retention and/o... Details Scopolamine Glucagon Injection Baqsimi Increased risk of gastrointestinal side effects Details Scopolamine Glucagon Injection / Solution Baqsimi Increased risk of gastrointestinal side effects Details Scopolamine Glucagon Nasal Powder Baqsimi Increased risk of gastrointestinal side effects Details Scopolamine Glycopyrronium Topical Cuvposa® Increased or potentiated scopolamine effects, an increased risk of CNS adverse reactions and an increased risk of intestinal obstr... Details Scopolamine Hydromorphone Injection Dilaudid Increased risk of urinary retention and/or severe constipation leading to paralytic ileus, increased or potentiated scopolamine ef... Details Scopolamine Hydromorphone Rectal available generically Increased risk of urinary retention and/or severe constipation leading to paralytic ileus, increased or potentiated scopolamine ef... Details Scopolamine Hydroxychloroquine Plaquenil An increased risk of seizures Details Scopolamine Ipratropium Nasal Spray Atrovent Nasal Spray® Increased or potentiated scopolamine effects, an increased risk of CNS adverse reactions and an increased risk of intestinal obstr... Details Scopolamine Ipratropium Oral Inhalation Atrovent® HFA Increased or potentiated scopolamine effects, an increased risk of CNS adverse reactions and an increased risk of intestinal obstr... Details Scopolamine Midazolam Nasal Spray Nayzilam Increased or potentiated scopolamine effects and an increased risk of CNS depression Details Scopolamine Midazolam Injection Nayzilam Increased or potentiated scopolamine effects and an increased risk of CNS depression Details Scopolamine Morphine Injection Astramorph® PF Increased risk of urinary retention, severe constipation, and paralytic ileus and an increased risk of profound sedation, respirat... Details Scopolamine Nalbuphine Injection Nubain® Increased or potentiated scopolamine effects and an increased risk of CNS depression Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.