Sertraline

532 interactions 409 explained in plain English 979 cited references

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Sparfloxacin Fluconazole Furazolidone Toloxatone Thioridazine Terfenadine

36 Contraindicated 477 Major 18 Moderate 1 Minor

All (532) Contraindicated (36) Major (477) Moderate (18) Minor (1)

Major

Sertraline Protriptyline Explained Increased risk of serotonin syndrome and an increased risk of QT interval prolongation Details Sertraline Quetiapine Seroquel Explained An increased risk of QT interval prolongation Details Sertraline Quinidine Cardioquin® Explained An increased risk of QT interval prolongation Details Sertraline Quinine Explained An increased risk of QT interval prolongation Details Sertraline Quizartinib Vanflyta Explained An increased risk of QT interval prolongation Details Sertraline Ranolazine Aspruzyo Explained An increased risk of QT interval prolongation Details Sertraline Relacorilant Lifyorli Explained Increased CYP3A4 substrate exposure and an increased risk of CYP3A4-substrate-related adverse reactions Details Sertraline Relugolix Orgovyx Explained Increased risk of QT interval prolongation Details Sertraline Remifentanil Explained Increased risk of serotonin syndrome Details Sertraline Reviparin Explained An increased risk of bleeding Details Sertraline Revumenib Revuforj Explained An increased risk of QT interval prolongation Details Sertraline Ribociclib Kisqali Explained An increased risk of QT interval prolongation Details Sertraline Rilpivirine Edurant Explained An increased risk of QT interval prolongation and torsade de pointes Details Sertraline Risperidone Perseris Explained Increased risperiDONE exposure and an increased risk of QT interval prolongation Details Sertraline Ritonavir Norvir Explained Increased sertraline exposure and an increased risk of QT interval prolongation Details Sertraline Rivaroxaban Xarelto Explained Increased risk of bleeding Details Sertraline Rizatriptan Explained An increased risk of serotonin syndrome Details Sertraline Rofecoxib Explained An increased risk of bleeding Details Sertraline Salicylic Acid Explained An increased risk of bleeding Details Sertraline Salsalate Disalcid Explained An increased risk of bleeding Details Sertraline Selexipag Uptravi Explained An increased risk of bleeding Details Sertraline Selpercatinib Retevmo Explained Increased risk of QT interval prolongation Details Sertraline Sertindole Explained An increased risk of QT interval prolongation Details Sertraline Sevoflurane Petrem Explained An increased risk of QT interval prolongation Details Sertraline Sibutramine Explained An increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Sertraline Siponimod Mayzent Explained An increased risk of QT interval prolongation Details Sertraline Sodium Phosphate OsmoPrep Explained An increased risk of QT interval prolongation Details Sertraline Sodium Phosphate, Dibasic Explained An increased risk of QT interval prolongation Details Sertraline Sodium Phosphate, Monobasic Explained An increased risk of QT interval prolongation Details Sertraline Sodium Salicylate Explained An increased risk of bleeding Details Sertraline Sofpironium Explained Increased CYP2D6 substrate exposure Details Sertraline Solifenacin Vesicare Explained An increased risk of QT interval prolongation Details Sertraline Sorafenib Nexavar Explained An increased risk of QT interval prolongation Details Sertraline Sotalol Betapace Explained An increased risk of QT interval prolongation Details Sertraline St John's Wort Explained An increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Sertraline Sufentanil Dsuvia Explained Increased risk of serotonin syndrome Details Sertraline Sulfinpyrazone Explained An increased risk of bleeding Details Sertraline Sulindac Clinoril® Explained An increased risk of bleeding Details Sertraline Sulodexide Explained An increased risk of bleeding Details Sertraline Sulpiride Explained An increased risk of QT interval prolongation Details

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