Sertraline

532 interactions 409 explained in plain English 979 cited references

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Sparfloxacin Fluconazole Furazolidone Toloxatone Thioridazine Terfenadine

36 Contraindicated 477 Major 18 Moderate 1 Minor

All (532) Contraindicated (36) Major (477) Moderate (18) Minor (1)

Major

Sertraline Sultopride Explained An increased risk of QT interval prolongation Details Sertraline Sumatriptan Imitrex Explained An increased risk of serotonin syndrome Details Sertraline Sunitinib Sutent Explained An increased risk of QT interval prolongation Details Sertraline Tacrolimus Astagraf Explained An increased risk of QT interval prolongation Details Sertraline Taletrectinib Ibtrozi Explained Increased risk of QT interval prolongation and torsade de pointes Details Sertraline Tamoxifen Nolvadex® Explained Reduced exposure of active tamoxifen metabolites and an increased risk of QT interval prolongation Details Sertraline Tamsulosin Flomax Explained Increased CYP2D6 substrate exposure Details Sertraline Tapentadol Nucynta Explained An increased risk of serotonin syndrome Details Sertraline Tazemetostat Tazverik Explained Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Sertraline Tedizolid Phosphate Sivextro Explained An increased risk of serotonin syndrome Details Sertraline Telaprevir Explained An increased risk of QT interval prolongation Details Sertraline Telavancin Vibativ Explained An increased risk of QT interval prolongation Details Sertraline Telithromycin Explained An increased risk of QT interval prolongation Details Sertraline Tenoxicam Explained An increased risk of bleeding Details Sertraline Tetrabenazine Xenazine Explained Increased risk of QT interval prolongation and an increased CYP2D6 substrate exposure Details Sertraline Tianeptine Explained An increased risk of serotonin syndrome Details Sertraline Tiaprofenic Acid Explained An increased risk of bleeding Details Sertraline Ticagrelor Brilinta Explained An increased risk of bleeding Details Sertraline Ticlopidine Ticlid® Explained An increased risk of bleeding Details Sertraline Tilidine Explained An increased risk of serotonin syndrome Details Sertraline Timolol Betimol Explained Increased CYP2D6 substrate exposure Details Sertraline Tinzaparin Explained An increased risk of bleeding Details Sertraline Tirofiban Explained An increased risk of bleeding Details Sertraline Tolfenamic Acid Explained An increased risk of bleeding Details Sertraline Tolmetin Tolectin 600 Explained An increased risk of bleeding Details Sertraline Tolterodine Detrol Explained Increased risk of QT interval prolongation and an increased CYP2D6 substrate exposure Details Sertraline Toremifene Fareston Explained An increased risk of QT interval prolongation Details Sertraline Tramadol ConZip Explained Increased traMADol exposure and reduced exposure of the active metabolite M1, increased risk for serotonin syndrome Details Sertraline Trazodone Raldesy Explained Increased risk of serotonin syndrome and an increased risk of QT interval prolongation Details Sertraline Treprostinil Orenitram Explained An increased risk of bleeding Details Sertraline Triclabendazole Egaten Explained An increased risk of QT interval prolongation Details Sertraline Trimipramine Explained Increased CYP2D6 substrate exposure, an increased risk of serotonin syndrome and an increased risk of QT interval prolongation Details Sertraline Triptorelin Explained An increased risk of QT interval prolongation Details Sertraline Tryptophan Explained An increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Sertraline Valbenazine Ingrezza Explained Increased CYP2D6 substrate exposure Details Sertraline Valdecoxib Explained An increased risk of bleeding Details Sertraline Vandetanib Caprelsa Explained An increased risk of QT interval prolongation Details Sertraline Vardenafil Levitra Explained An increased risk of QT interval prolongation Details Sertraline Vemurafenib Zelboraf Explained An increased risk of QT interval prolongation Details Sertraline Venlafaxine Explained Increased CYP2D6 substrate exposure, an increased risk of serotonin syndrome and an increased risk of QT interval prolongation Details

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