Sertraline

532 interactions 409 explained in plain English 979 cited references
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Sertraline Vepdegestrant Veppanu Explained An increased risk of QT interval prolongation and an increased risk of torsade de pointes, polymorphic ventricular tachycardia, ot... Details Sertraline Vilanterol Explained An increased risk of QT interval prolongation Details Sertraline Vilazodone Viibryd Explained Increased risk for serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Sertraline Vinflunine Explained An increased risk of QT interval prolongation Details Sertraline Voclosporin Lupkynis Explained An increased risk of QT interval prolongation Details Sertraline Vorapaxar Zontivity Explained An increased risk of bleeding Details Sertraline Voriconazole Vfend Explained An increased risk of QT interval prolongation, an increased sertraline exposure and an increased risk of sertraline-related advers... Details Sertraline Vorinostat Zolinza Explained An increased risk of QT interval prolongation Details Sertraline Vortioxetine Trintellix Explained Increased CYP2D6 substrate exposure and an increased risk of serotonin syndrome Details Sertraline Warfarin Coumadin Explained An increased risk of bleeding, increased sertraline exposure and an increased risk of sertraline-related adverse events Details Sertraline Xanomeline Explained Increased CYP2D6 substrate exposure Details Sertraline Yohimbine Explained Increased CYP2D6 substrate exposure Details Sertraline Ziftomenib Komzifti Explained An increased risk of QT interval prolongation and torsade de pointes Details Sertraline Zolmitriptan Zomig Explained An increased risk of serotonin syndrome Details Sertraline Zolpidem Ambien Explained Increased zolpidem exposure Details Sertraline Zotepine Explained An increased risk of QT interval prolongation Details Sertraline Zuclopenthixol Explained Increased risk of QT interval prolongation and an increased CYP2D6 substrate exposure Details Sertraline Buprenorphine Belbuca Explained Increased risk of serotonin syndrome and an increased risk of QT interval prolongation Details Sertraline Trospium / Xanomeline Cobenfy Explained Increased CYP2D6 substrate exposure Details Sertraline Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Sertraline Aripiprazole Injection Abilify Increased risk of QT interval prolongation and an increased CYP2D6 substrate exposure Details Sertraline Arsenic Trioxide Injection Trisenox An increased risk of QT interval prolongation Details Sertraline Asenapine Transdermal Patch Secuado An increased risk of QT interval prolongation Details Sertraline Aspirin Rectal Aspirin An increased risk of bleeding Details Sertraline Bromfenac Ophthalmic Bromday® An increased risk of bleeding Details Sertraline Butorphanol Injection Butorphic Increased risk of serotonin syndrome Details Sertraline Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome Details Sertraline Dabigatran Pradaxa® An increased risk of bleeding Details Sertraline Dalteparin Injection Fragmin An increased risk of bleeding Details Sertraline Degarelix Injection Firmagon An increased risk of QT interval prolongation Details Sertraline Diclofenac Ophthalmic Voltaren® Eye Drops An increased risk of bleeding Details Sertraline Diclofenac Topical (Actinic Keratosis) Pennsaid An increased risk of bleeding Details Sertraline Diclofenac Topical (Arthritis Pain) Pennsaid® An increased risk of bleeding Details Sertraline Diclofenac Transdermal Patch Flector An increased risk of bleeding Details Sertraline Dolasetron Injection Anzemet Increased risk of serotonin syndrome and an increased risk of QT interval prolongation Details Sertraline Enoxaparin Injection Lovenox An increased risk of bleeding Details Sertraline Eribulin Injection Halaven An increased risk of QT interval prolongation Details Sertraline Famotidine Injection Calmicid An increased risk of QT interval prolongation Details Sertraline Fentanyl Transdermal Patch Duragesic® Increased risk of serotonin syndrome Details Sertraline Flurbiprofen Ophthalmic Ocufen An increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.