Sertraline

532 interactions 409 explained in plain English 979 cited references

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Sparfloxacin Fluconazole Furazolidone Toloxatone Thioridazine Terfenadine

36 Contraindicated 477 Major 18 Moderate 1 Minor

All (532) Contraindicated (36) Major (477) Moderate (18) Minor (1)

Major

Sertraline Pacritinib Vonjo® Explained An increased risk of QT interval prolongation Details Sertraline Paliperidone Erzofri Explained An increased risk of QT interval prolongation Details Sertraline Palonosetron Explained An increased risk of serotonin syndrome Details Sertraline Panobinostat Farydak Explained An increased risk of QT interval prolongation Details Sertraline Papaveretum Explained An increased risk of serotonin syndrome Details Sertraline Papaverine Pavacot® Explained An increased risk of QT interval prolongation Details Sertraline Parecoxib Explained An increased risk of bleeding Details Sertraline Paregoric Explained An increased risk of serotonin syndrome Details Sertraline Parnaparin Explained An increased risk of bleeding Details Sertraline Paroxetine Paxil Explained Increased CYP2D6 substrate exposure, an increased risk of serotonin syndrome and an increased risk of QT interval prolongation Details Sertraline Pasireotide Signifor Explained An increased risk of QT interval prolongation Details Sertraline Pazopanib Votrient Explained An increased risk of QT interval prolongation Details Sertraline Pentamidine NebuPent Explained An increased risk of QT interval prolongation Details Sertraline Pentazocine Explained Increased risk of serotonin syndrome Details Sertraline Perphenazine Explained Increased risk of QT interval prolongation and an increased CYP2D6 substrate exposure Details Sertraline Phenindione Explained An increased risk of bleeding Details Sertraline Phenobarbital Fidoquel Explained An increased risk of QT interval prolongation Details Sertraline Phenprocoumon Explained An increased risk of bleeding Details Sertraline Phenylbutazone Equi-Phar Explained An increased risk of bleeding Details Sertraline Phenytoin Dilantin Explained Increased risk of phenytoin toxicity and reduced efficacy of sertraline Details Sertraline Piketoprofen Explained An increased risk of bleeding Details Sertraline Pimavanserin Nuplazid Explained An increased risk of QT interval prolongation Details Sertraline Pipamperone Explained An increased risk of QT interval prolongation Details Sertraline Piritramide Explained An increased risk of serotonin syndrome Details Sertraline Piroxicam Feldene Explained An increased risk of bleeding Details Sertraline Pitolisant Wakix Explained Increased risk of QT interval prolongation and an increased CYP2D6 substrate exposure Details Sertraline Ponesimod Ponvory Explained An increased risk of QT interval prolongation Details Sertraline Pranoprofen Explained An increased risk of bleeding Details Sertraline Prasugrel Effient Explained An increased risk of bleeding Details Sertraline Primaquine Primaryl® Explained Increased CYP2D6 substrate exposure Details Sertraline Primidone Mysoline Explained An increased risk of QT interval prolongation Details Sertraline Probucol Explained An increased risk of QT interval prolongation Details Sertraline Procainamide Procan® Explained An increased risk of QT interval prolongation Details Sertraline Prochlorperazine Explained An increased risk of QT interval prolongation Details Sertraline Proglumetacin Explained An increased risk of bleeding Details Sertraline Promethazine Phenadoz Explained An increased risk of QT interval prolongation Details Sertraline Propafenone Rythmol Explained Increased propafenone exposure and risk toxicity (cardiac arrhythmias) and an increased risk of QT interval prolongation Details Sertraline Propyphenazone Explained An increased risk of bleeding Details Sertraline Proquazone Explained An increased risk of bleeding Details Sertraline Protein C Ceprotin Explained An increased risk of bleeding Details

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