Sertraline

532 interactions 409 explained in plain English 979 cited references

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Sparfloxacin Fluconazole Furazolidone Toloxatone Thioridazine Terfenadine

36 Contraindicated 477 Major 18 Moderate 1 Minor

All (532) Contraindicated (36) Major (477) Moderate (18) Minor (1)

Major

Sertraline Moricizine Explained An increased risk of QT interval prolongation Details Sertraline Morniflumate Explained An increased risk of bleeding Details Sertraline Morphine Explained Increased risk of serotonin syndrome Details Sertraline Morphine Sulfate Liposome Explained Increased risk of serotonin syndrome Details Sertraline Moxifloxacin Avelox An increased risk of QT interval prolongation Details Sertraline Nabumetone Relafen An increased risk of bleeding Details Sertraline Nadroparin Explained An increased risk of bleeding Details Sertraline Nafarelin Explained An increased risk of QT interval prolongation Details Sertraline Nalbuphine Explained Increased risk of serotonin syndrome Details Sertraline Naproxen Aleve An increased risk of bleeding Details Sertraline Naratriptan Explained An increased risk of serotonin syndrome Details Sertraline Nebivolol Bystolic Increased exposure to nebivolol Details Sertraline Nefazodone Explained An increased risk of serotonin syndrome Details Sertraline Nelfinavir Viracept Explained An increased risk of QT interval prolongation Details Sertraline Nepafenac Ilevro Explained An increased risk of bleeding Details Sertraline Nicomorphine Explained An increased risk of serotonin syndrome Details Sertraline Niflumic Acid Explained An increased risk of bleeding Details Sertraline Nilotinib Explained An increased risk of QT interval prolongation Details Sertraline Nimesulide Explained An increased risk of bleeding Details Sertraline Nimesulide Beta Cyclodextrin Explained An increased risk of bleeding Details Sertraline Norfloxacin Explained An increased risk of QT interval prolongation Details Sertraline Nortriptyline Explained Increased nortriptyline exposure and an increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status... Details Sertraline Octreotide Bynfezia An increased risk of QT interval prolongation Details Sertraline Ofloxacin Floxin® An increased risk of QT interval prolongation Details Sertraline Olanzapine Explained An increased risk of QT interval prolongation Details Sertraline Oliceridine Olinvyk Explained Increased oliceridine exposure, and an increased risk of serotonin syndrome Details Sertraline Olodaterol Striverdi Explained An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Details Sertraline Omaveloxolone Skyclarys Explained Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Sertraline Ondansetron Explained Increased CYP2D6 substrate exposure, an increased risk of serotonin syndrome and an increased risk of QT interval prolongation Details Sertraline Opipramol Explained An increased risk of serotonin syndrome Details Sertraline Opium Explained An increased risk of serotonin syndrome Details Sertraline Opium Alkaloids Explained An increased risk of serotonin syndrome Details Sertraline Osilodrostat Isturisa Explained Increased risk of QT interval prolongation Details Sertraline Osimertinib Tagrisso Explained Increased risk of QT interval prolongation Details Sertraline Oxaliplatin Explained Increased risk of QT-interval prolongation Details Sertraline Oxaprozin Coxanto Explained An increased risk of bleeding Details Sertraline Oxcarbazepine Oxtellar Explained An increased risk of serotonin syndrome Details Sertraline Oxycodone Oxaydo Explained Increased oxyCODONE exposure and an increased risk of serotonin syndrome Details Sertraline Oxymorphone Explained Increased risk of serotonin syndrome Details Sertraline Oxyphenbutazone Explained An increased risk of bleeding Details

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