Sertraline

532 interactions 409 explained in plain English 979 cited references

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Sparfloxacin Fluconazole Furazolidone Toloxatone Thioridazine Terfenadine

36 Contraindicated 477 Major 18 Moderate 1 Minor

All (532) Contraindicated (36) Major (477) Moderate (18) Minor (1)

Major

Sertraline Letermovir Prevymis Explained Increased CYP3A substrate exposure Details Sertraline Leuprolide Eligard Explained An increased risk of QT interval prolongation Details Sertraline Levofloxacin Levaquin An increased risk of QT interval prolongation Details Sertraline Levomilnacipran Explained An increased risk of serotonin syndrome Details Sertraline Levorphanol Xyvona Explained An increased risk of serotonin syndrome Details Sertraline Lisdexamfetamine Arynta Explained Increased amphetamine exposure and an increased risk of serotonin syndrome Details Sertraline Lithium Explained An increased risk of serotonin syndrome Details Sertraline Lofepramine Explained Modest elevations in lofepramine exposure and an increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, ment... Details Sertraline Lofexidine Explained Increased risk of QT interval prolongation and an increased CYP2D6 substrate exposure Details Sertraline Lonafarnib Zokinvy Explained An increased risk of QT interval prolongation and torsade de pointes Details Sertraline Loperamide Diamode An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Sertraline Loratadine Agistam® Increased CYP2D6 substrate exposure Details Sertraline Lorcaserin Explained Increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) Details Sertraline Lornoxicam Explained An increased risk of bleeding Details Sertraline Loxoprofen Explained An increased risk of bleeding Details Sertraline Lumefantrine Explained An increased risk of QT interval prolongation Details Sertraline Lumiracoxib Explained An increased risk of bleeding Details Sertraline Macimorelin Explained An increased risk of QT interval prolongation Details Sertraline Maprotiline Ludiomil® Increased CYP2D6 substrate exposure Details Sertraline Mavorixafor Xolremdi Explained An increased risk of QT interval prolongation and torsade de pointes Details Sertraline Meclofenamate Meclodium® An increased risk of bleeding Details Sertraline Mefenamic Acid Ponstel® An increased risk of bleeding Details Sertraline Mefloquine Lariam® An increased risk of QT interval prolongation Details Sertraline Melitracen Explained An increased risk of serotonin syndrome Details Sertraline Meloxicam Alloxate An increased risk of bleeding Details Sertraline Meperidine Demerol Explained Increased risk of serotonin syndrome Details Sertraline Metaxalone Skelaxin Explained Increased risk of serotonin syndrome Details Sertraline Methadone Diskets Explained Increased QT interval prolongation, increased risk of serotonin syndrome, increased methadone exposure and an increased risk of op... Details Sertraline Methamphetamine Desoxyn Explained Increased amphetamine exposure and an increased risk of serotonin syndrome Details Sertraline Methotrimeprazine Explained An increased risk of QT interval prolongation Details Sertraline Methylphenidate Adhansia XR® Increased selective serotonin reuptake inhibitor exposure Details Sertraline Metoprolol Kapspargo Explained Increased CYP2D6 substrate exposure Details Sertraline Metronidazole Flagyl An increased risk of QT interval prolongation Details Sertraline Mexiletine Mexitil® Increased CYP2D6 substrate exposure Details Sertraline Mifepristone Korlym Explained Increased sertraline exposure and an increased risk of QT interval prolongation Details Sertraline Milnacipran Savella Explained An increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Sertraline Milsaperidone Explained An increased risk of QT interval prolongation Details Sertraline Mirtazapine Mirataz Explained Increased risk of serotonin syndrome, an increased risk of QT interval prolongation and an increased risk of torsades de pointes Details Sertraline Mizolastine Explained An increased risk of QT interval prolongation Details Sertraline Mobocertinib Exkivity Explained An increased risk of QT interval prolongation Details

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