Sertraline

532 interactions 409 explained in plain English 979 cited references

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Sparfloxacin Fluconazole Furazolidone Toloxatone Thioridazine Terfenadine

36 Contraindicated 477 Major 18 Moderate 1 Minor

All (532) Contraindicated (36) Major (477) Moderate (18) Minor (1)

Major

Sertraline Gepotidacin Blujepa Explained An increased risk of QT interval prolongation Details Sertraline Gilteritinib Xospata Decreased effects of drugs that target the 5HT2B receptor or the sigma nonspecific receptor Details Sertraline Givinostat Duvyzat Explained Increased risk of QT interval prolongation and torsade de pointes Details Sertraline Glasdegib Daurismo Increased risk of QT interval prolongation Details Sertraline Gonadorelin Explained An increased risk of QT interval prolongation Details Sertraline Goserelin Explained An increased risk of QT interval prolongation Details Sertraline Granisetron Explained Increased risk of serotonin syndrome and an increased risk of QT interval prolongation Details Sertraline Halofantrine Explained An increased risk of QT interval prolongation Details Sertraline Haloperidol Explained Increased haloperidol exposure and an increased risk of QT interval prolongation Details Sertraline Heparin An increased risk of bleeding Details Sertraline Histrelin Supprelin Explained An increased risk of QT interval prolongation Details Sertraline Hydrocodone Hysingla Explained An increased risk of serotonin syndrome Details Sertraline Hydromorphone Dilaudid Explained Increased risk of serotonin syndrome Details Sertraline Hydroquinidine Explained An increased risk of QT interval prolongation Details Sertraline Hydroxychloroquine Plaquenil An increased risk of seizures and an increased risk of QT interval prolongation Details Sertraline Hydroxytryptophan Explained An increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Sertraline Hydroxyzine Explained An increased risk of QT interval prolongation Details Sertraline Ibuprofen Addaprin An increased risk of bleeding Details Sertraline Ibutilide Corvert Explained An increased risk of QT interval prolongation Details Sertraline Iloperidone Fanapt Explained Increased risk of QT interval prolongation and an increased CYP2D6 substrate exposure Details Sertraline Iloprost Aurlumyn An increased risk of bleeding Details Sertraline Imipramine Explained Increased CYP2D6 substrate exposure, an increased risk of serotonin syndrome and an increased risk of QT interval prolongation Details Sertraline Indomethacin Indocin Explained An increased risk of bleeding Details Sertraline Inotuzumab Ozogamicin Besponsa Explained An increased risk of QT interval prolongation Details Sertraline Iobenguane I 123 Explained Potential for false negative imaging results Details Sertraline Iobenguane I 131 Azedra Explained Inaccurate dosimetry calculations or reduced efficacy Details Sertraline Ioflupane I 123 Explained Interference with ioflupane I 123 imaging Details Sertraline Isoflurane Fluriso Explained An increased risk of QT interval prolongation and torsade de pointes Details Sertraline Itraconazole Sporanox Explained An increased risk of QT interval prolongation Details Sertraline Ivabradine Corlanor An increased risk of QT interval prolongation Details Sertraline Ivosidenib Tibsovo Explained An increased risk of QT interval prolongation Details Sertraline Ketobemidone Explained An increased risk of serotonin syndrome Details Sertraline Ketoprofen Actron® An increased risk of bleeding Details Sertraline Ketorolac Acular An increased risk of bleeding Details Sertraline Kratom Explained Increased CYP3A substrate exposure and increased risk of serotonin syndrome Details Sertraline Lapatinib Tykerb Explained An increased risk of QT interval prolongation Details Sertraline Lasmiditan Reyvow Explained Increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Sertraline Lefamulin Xenleta Increased risk of QT interval prolongation Details Sertraline Lenvatinib Lenvima Increased risk of QT-interval prolongation Details Sertraline Lepirudin Explained An increased risk of bleeding Details

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