Sertraline

532 interactions 409 explained in plain English 979 cited references

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Sparfloxacin Fluconazole Furazolidone Toloxatone Thioridazine Terfenadine

36 Contraindicated 477 Major 18 Moderate 1 Minor

All (532) Contraindicated (36) Major (477) Moderate (18) Minor (1)

Major

Sertraline Enoxaparin Lovenox An increased risk of bleeding Details Sertraline Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Sertraline Epoprostenol Flolan An increased risk of bleeding Details Sertraline Eptifibatide Explained An increased risk of bleeding Details Sertraline Eribulin Halaven Explained An increased risk of QT interval prolongation Details Sertraline Erythromycin Erythrocin Stearate Explained An increased risk of QT interval prolongation, an increased sertraline exposure and an increased risk of sertraline-related advers... Details Sertraline Escitalopram Lexapro Explained Increased risk of serotonin syndrome and an increased risk of QT interval prolongation Details Sertraline Ethylmorphine Explained An increased risk of serotonin syndrome Details Sertraline Etodolac Lodine An increased risk of bleeding Details Sertraline Etofenamate Explained An increased risk of bleeding Details Sertraline Etoricoxib Explained An increased risk of bleeding Details Sertraline Etrasimod Velsipity Explained Increased risk of transient reduction in heart rate, AV conduction, QT interval prolongation and an increased risk of torsade de p... Details Sertraline Famotidine Calmicid An increased risk of QT interval prolongation Details Sertraline Felbamate Felbatol An increased risk of QT interval prolongation Details Sertraline Felbinac Explained An increased risk of bleeding Details Sertraline Fenfluramine Explained Increased CYP2D6 substrate exposure and an increased risk of serotonin syndrome Details Sertraline Fenoprofen Fenopron An increased risk of bleeding Details Sertraline Fentanyl Explained Increased risk of serotonin syndrome Details Sertraline Fepradinol Explained An increased risk of bleeding Details Sertraline Feprazone Explained An increased risk of bleeding Details Sertraline Fexinidazole Explained An increased risk of QT interval prolongation Details Sertraline Fingolimod Gilenya Explained An increased risk of QT interval prolongation Details Sertraline Flecainide Tambocor® An increased risk of QT interval prolongation, an increased flecainide exposure and risk for toxicity (cardiac arrhythmia) Details Sertraline Floctafenine Explained An increased risk of bleeding Details Sertraline Flufenamic Acid Explained An increased risk of bleeding Details Sertraline Fluoxetine RECONCILE Explained Increased CYP2D6 substrate exposure, an increased risk of serotonin syndrome and an increased risk of QT interval prolongation Details Sertraline Flurbiprofen Ansaid An increased risk of bleeding Details Sertraline Fluvoxamine Explained An increased risk of serotonin syndrome Details Sertraline Fondaparinux Arixtra An increased risk of bleeding Details Sertraline Formoterol Perforomist Explained An increased risk of QT interval prolongation Details Sertraline Foscarnet Foscavir Explained An increased risk of QT interval prolongation Details Sertraline Fosfomycin Contepo Explained An increased risk of QT interval prolongation Details Sertraline Fosphenytoin Cerebyx Explained Increased risk of fosphenytoin toxicity, reduced efficacy of sertraline and an increased risk of QT interval prolongation Details Sertraline Fostemsavir Rukobia Increased risk of torsade de pointes Details Sertraline Frovatriptan Frova Explained An increased risk of serotonin syndrome Details Sertraline Galantamine Razadyne An increased risk of QT interval prolongation Details Sertraline Gatifloxacin Zymaxid Explained An increased risk of QT interval prolongation Details Sertraline Gefitinib Iressa Increased CYP2D6 substrate exposure Details Sertraline Gemifloxacin Factive An increased risk of QT interval prolongation Details Sertraline Gepirone Exxua Explained Increased risk of serotonin syndrome and an increased risk of QT interval prolongation and cardiac arrhythmias Details

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