Sertraline
532 interactions 409 explained in plain English 979 cited references
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
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· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
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Sertraline Delamanid Explained An increased risk of QT interval prolongation Details Sertraline Desflurane Suprane Explained An increased risk of QT interval prolongation Details Sertraline Desipramine Norpramin Explained Increased CYP2D6 substrate exposure, an increased risk of serotonin syndrome and an increased risk of QT interval prolongation Details Sertraline Desirudin Iprivask Explained An increased risk of bleeding Details Sertraline Deslorelin Explained An increased risk of QT interval prolongation Details Sertraline Desvenlafaxine Pristiq Explained Increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) Details Sertraline Deutetrabenazine Austedo Increased risk of QT interval prolongation and an increased CYP2D6 substrate exposure Details Sertraline Dexfenfluramine Explained Serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Sertraline Dexibuprofen Explained An increased risk of bleeding Details Sertraline Dexketoprofen Explained An increased risk of bleeding Details Sertraline Dexmedetomidine Dexased Explained Increased risk of cardiac arrhythmias Details Sertraline Dextroamphetamine Dexedrine Explained Increased amphetamine exposure and an increased risk of serotonin syndrome Details Sertraline Dextromethorphan Delsym Explained Increased dextromethorphan exposure and an increased risk of serotonin syndrome Details Sertraline Dibenzepin Explained An increased risk of serotonin syndrome Details Sertraline Diclofenac Aleve Arthritis Pain Explained An increased risk of bleeding Details Sertraline Difenoxin Explained An increased risk of serotonin syndrome Details Sertraline Diflunisal Dolobid Explained An increased risk of bleeding Details Sertraline Dihydrocodeine Explained Increased dihydrocodeine exposure, reduced exposure of active metabolite, and increased risk of serotonin syndrome Details Sertraline Diphenoxylate Explained An increased risk of serotonin syndrome Details Sertraline Dipyridamole Permole® An increased risk of bleeding Details Sertraline Dipyrone Explained An increased risk of bleeding and a reduced sertraline exposure Details Sertraline Disopyramide Norpace An increased risk of QT interval prolongation Details Sertraline Dofetilide Tikosyn An increased risk of QT interval prolongation Details Sertraline Dolasetron Anzemet Increased risk of serotonin syndrome and an increased risk of QT interval prolongation Details Sertraline Domperidone Explained An increased risk of QT interval prolongation Details Sertraline Donepezil Adlarity Explained An increased risk of QT interval prolongation Details Sertraline Dordaviprone Explained An increased risk of QT interval prolongation Details Sertraline Dothiepin Explained Modest elevations in dothiepin serum levels or possible serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status c... Details Sertraline Doxepin Prudoxin Explained Increased CYP2D6 substrate exposure, an increased risk of serotonin syndrome and an increased risk of QT interval prolongation Details Sertraline Doxorubicin Adriamycin Increased CYP2D6 substrate exposure Details Sertraline Doxorubicin Hydrochloride Liposome Explained Increased CYP2D6 substrate exposure Details Sertraline Droperidol Explained An increased risk of QT interval prolongation Details Sertraline Droxicam Explained An increased risk of bleeding Details Sertraline Duloxetine Explained Increased CYP2D6 substrate exposure and an increased risk of serotonin syndrome Details Sertraline Ebastine Explained An increased risk of QT interval prolongation Details Sertraline Edoxaban Savaysa An increased risk of bleeding Details Sertraline Efavirenz Explained Reduced sertraline exposure and an increased risk of QT interval prolongation Details Sertraline Eletriptan Relpax Explained Increased risk of serotonin syndrome Details Sertraline Encainide Explained Increased CYP2D6 substrate exposure Details Sertraline Encorafenib Braftovi Increased risk of QT interval prolongation DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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