Sertraline
532 interactions 409 explained in plain English 979 cited references
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
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· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
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Sertraline Bufexamac Explained An increased risk of bleeding Details Sertraline Bupropion Aplenzin Explained Increased sertraline exposure, an increased risk of seizure, severe head injury, arteriovenous malformations, CNS tumor or CNS inf... Details Sertraline Buserelin Explained An increased risk of QT interval prolongation Details Sertraline Buspirone Bucapsol Explained An increased risk of serotonin syndrome Details Sertraline Butorphanol Butorphic Explained Increased risk of serotonin syndrome Details Sertraline Cangrelor Kengreal Explained An increased risk of bleeding Details Sertraline Carbamazepine Carbatrol Explained Reduced sertraline exposure and an increased risk of serotonin syndrome Details Sertraline Carvedilol Coreg Explained Increased CYP2D6 substrate exposure Details Sertraline Celecoxib Celebrex Explained An increased risk of bleeding Details Sertraline Ceritinib Zykadia Explained An increased risk of QT interval prolongation Details Sertraline Certoparin Explained An increased risk of bleeding Details Sertraline Chloroquine Aralen® An increased risk of QT interval prolongation Details Sertraline Chlorpheniramine Explained Increased CYP2D6 substrate exposure and an increased risk of serotonin syndrome Details Sertraline Chlorpromazine Explained An increased risk of QT interval prolongation Details Sertraline Choline Salicylate Explained An increased risk of bleeding Details Sertraline Cilostazol Pletal® Explained An increased risk of bleeding Details Sertraline Ciprofloxacin Explained An increased risk of QT interval prolongation Details Sertraline Citalopram Celexa Explained Increased risk of serotonin syndrome and an increased risk of QT interval prolongation Details Sertraline Clarithromycin Biaxin Explained Increased risk of QT interval prolongation, increased exposure of CYP3A4 substrate and risk for toxicity Details Sertraline Clofazimine Explained An increased risk of QT interval prolongation Details Sertraline Clomipramine Anafranil Explained Increased CYP2D6 substrate exposure, an increased risk of serotonin syndrome and an increased risk of QT interval prolongation Details Sertraline Clonixin Explained An increased risk of bleeding Details Sertraline Clopidogrel Plavix An increased risk of bleeding Details Sertraline Clothiapine Explained Increased risk of cardiac arrhythmias Details Sertraline Clozapine Clozaril Explained Increased clozapine exposure and risk of QT prolongation Details Sertraline Cobicistat Tybost Explained Increased sertraline exposure Details Sertraline Cocaine Goprelto Explained An increased risk of serotonin syndrome Details Sertraline Codeine Tuzistra XR® (as a combination product containing Chlorpheniramine, Codeine) Explained Increased risk of serotonin syndrome, increased codeine exposure and reduced active metabolite (morphine) exposure Details Sertraline Conivaptan Vaprisol Explained Increased CYP3A substrate exposure Details Sertraline Crizotinib Xalkori Explained An increased risk of QT interval prolongation Details Sertraline Cyclizine Explained Increased CYP2D6 substrate exposure Details Sertraline Cyclobenzaprine Amrix Explained Increased risk of serotonin syndrome and an increased risk of QT interval prolongation Details Sertraline Dabigatran Etexilate An increased risk of bleeding Details Sertraline Dabrafenib Tafinlar Explained An increased risk of QT interval prolongation Details Sertraline Dalteparin Fragmin Explained An increased risk of bleeding Details Sertraline Danaparoid Explained An increased risk of bleeding Details Sertraline Darifenacin Enablex Explained Increased CYP2D6 substrate exposure Details Sertraline Darunavir Explained Increased selective serotonin reuptake inhibitor (SSRI) exposure and an increased risk of SSRI-related adverse reactions Details Sertraline Dasatinib Phyrago An increased risk of QT interval prolongation Details Sertraline Degarelix Firmagon Explained An increased risk of QT interval prolongation DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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