Sertraline

532 interactions 409 explained in plain English 979 cited references

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Sparfloxacin Fluconazole Furazolidone Toloxatone Thioridazine Terfenadine

36 Contraindicated 477 Major 18 Moderate 1 Minor

All (532) Contraindicated (36) Major (477) Moderate (18) Minor (1)

Major

Sertraline Acemetacin Explained An increased risk of bleeding Details Sertraline Acenocoumarol Explained An increased risk of bleeding Details Sertraline Adagrasib Krazati Explained An increased risk of QT interval prolongation, torsade de pointes, polymorphic ventricular tachycardia, other serious arrhythmias Details Sertraline Alfentanil Explained Increased risk of serotonin syndrome Details Sertraline Alfuzosin UroXatral An increased risk of QT interval prolongation Details Sertraline Almotriptan Explained An increased risk of serotonin syndrome Details Sertraline Amineptine Explained An increased risk of serotonin syndrome Details Sertraline Amiodarone Nexterone Explained An increased risk of QT interval prolongation Details Sertraline Amisulpride Barhemsys Explained Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Sertraline Amitriptylinoxide Explained An increased risk of serotonin syndrome Details Sertraline Amoxapine Explained Modest elevation in amoxapine exposure and an increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental... Details Sertraline Amphetamine Dexedrine Explained Increased amphetamine exposure and an increased risk of serotonin syndrome Details Sertraline Amtolmetin Guacil Explained An increased risk of bleeding Details Sertraline Anagrelide Agrylin Increased risk of bleeding and an increased risk of QT interval prolongation Details Sertraline Anileridine Explained An increased risk of serotonin syndrome Details Sertraline Apalutamide Erleada Explained Reduced CYP3A4 substrate exposure Details Sertraline Apixaban Eliquis Explained An increased risk of bleeding and can cause serious, potentially fatal bleeding Details Sertraline Apomorphine Apokyn Explained An increased risk of QT interval prolongation Details Sertraline Ardeparin Explained An increased risk of bleeding Details Sertraline Argatroban Explained An increased risk of bleeding Details Sertraline Aripiprazole Abilify Explained Increased risk of QT interval prolongation and an increased CYP2D6 substrate exposure Details Sertraline Aripiprazole Lauroxil Aristada Explained Increased risk of QT interval prolongation and an increased CYP2D6 substrate exposure Details Sertraline Arsenic Trioxide Trisenox Explained An increased risk of QT interval prolongation Details Sertraline Artemether Explained An increased risk of QT interval prolongation, reduced CYP3A4 substrates exposure and reduced efficacy of CYP3A4 substrates Details Sertraline Asenapine Saphris Explained An increased risk of QT interval prolongation Details Sertraline Aspirin Acuprin® Explained An increased risk of bleeding Details Sertraline Astemizole Explained Increased astemizole exposure and an increased risk of cardiotoxicity (QT interval prolongation, torsades de pointes, cardiac arre... Details Sertraline Atazanavir Reyataz Explained An increased risk of QT interval prolongation Details Sertraline Atomoxetine Atoncy Explained Increased CYP2D6 substrate exposure Details Sertraline Avacopan Tavneos Explained Increased CYP3A4 substrate exposure Details Sertraline Azithromycin AzaSite An increased risk of QT interval prolongation Details Sertraline Bedaquiline Sirturo An increased risk of QT interval prolongation Details Sertraline Bemiparin Explained An increased risk of bleeding Details Sertraline Benzhydrocodone Explained An increased risk of serotonin syndrome Details Sertraline Benzphetamine Explained Increased amphetamine exposure and an increased risk of serotonin syndrome Details Sertraline Betrixaban Bevyxxa® An increased risk of bleeding Details Sertraline Bivalirudin Angiomax Explained An increased risk of bleeding Details Sertraline Brexpiprazole Rexulti Increased CYP2D6 substrate exposure Details Sertraline Bromfenac Bromsite Explained An increased risk of bleeding Details Sertraline Brompheniramine Respa-BR Explained An increased risk of serotonin syndrome Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.