Sodium Bicarbonate and Infigratinib: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Infigratinib
Sodium Bicarbonate
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Decreased infigratinib plasma concentrations
Interaction Deep Dive
Coadministration of infigratinib with gastric acid reducing agents, including antacids, may decrease infigratinib plasma concentrations, which may reduce the anti-tumor activity of infigratinib. Avoid concomitant use of infigratinib with locally-acting antacids; if coadministration cannot be avoided, separate administration of infigratinib by 2 hours before or after antacids. Coadministration of multiple doses of lansoprazole (proton pump inhibitor) decreased the exposure of infigratinib and its metabolites1.
Why it happens (mechanism)
Decreased gastric acid
Literature reports
1 report — tap to read
a) Coadministration of multiple doses of lansoprazole (proton pump inhibitor) decreased infigratinib AUC(0 to infinity) by 45% and Cmax by 49%, decreased metabolite BHS697 AUC(0 to infinity) by 32% and Cmax by 44%, and decreased metabolite CQM157 AUC(0 to infinity) by 72% and Cmax by 55%, respectively 1.
Common questions
Can I take Sodium Bicarbonate and Infigratinib together?
Decreased infigratinib plasma concentrations Always confirm with your pharmacist or prescriber before making any change.
How serious is the Sodium Bicarbonate and Infigratinib interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Sodium Bicarbonate or Infigratinib need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: TRUSELTIQ(TM) oral capsules, infigratinib oral capsules. QED Therapeutics Inc (per FDA), Brisbane, CA, 2021.
Keep reading about Infigratinib
Keep reading about Sodium Bicarbonate
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Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
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