Sodium Bicarbonate

26 interactions
Also sold as: Alka-Seltzer® Heartburn Desempacho Neut brand of sodium bicarbonate
About Sodium Bicarbonate

Sodium bicarbonate is an antacid used to relieve heartburn, acid indigestion, and to reduce acidity in blood or urine. Read the full Sodium Bicarbonate drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Octreotide Mefenamic Acid Neratinib Memantine Erdafitinib Gefitinib
14 Major 12 Moderate
All (26) Major (14) Moderate (12)

Major

Sodium Bicarbonate Acalabrutinib Calquence Reduced acalabrutinib exposure Details Sodium Bicarbonate Cabotegravir Apretude Reduced cabotegravir plasma concentrations Details Sodium Bicarbonate Cefuroxime Ceftin® Decreased cefuroxime axetil exposure Details Sodium Bicarbonate Digoxin Cardoxin® Reduced digoxin exposure Details Sodium Bicarbonate Erdafitinib Balversa Altered serum phosphate levels Details Sodium Bicarbonate Gefitinib Iressa Decreased exposure of gefitinib Details Sodium Bicarbonate Hydroxychloroquine Plaquenil Reduced hydroxychloroquine exposure Details Sodium Bicarbonate Infigratinib Truseltiq Decreased infigratinib plasma concentrations Details Sodium Bicarbonate Ketoconazole Topical Extina® Foam Reduced ketoconazole exposure and reduced efficacy of ketoconazole Details Sodium Bicarbonate Mefenamic Acid Ponstel® Increased exposure to mefenamic acid Details Sodium Bicarbonate Memantine Namenda Reduced renal clearance of memantine Details Sodium Bicarbonate Neratinib Nerlynx Decreased neratinib exposure Details Sodium Bicarbonate Octreotide Bynfezia Decreased octreotide bioavailability Details Sodium Bicarbonate Octreotide Injection Bynfezia Decreased octreotide bioavailability Details

Moderate

Sodium Bicarbonate Aspirin Acuprin® Decreased salicylate effectiveness Details Sodium Bicarbonate Aspirin Rectal Aspirin Decreased salicylate effectiveness Details Sodium Bicarbonate Bosutinib Bosulif Reduced bosutinib exposure Details Sodium Bicarbonate Cefpodoxime Banan® Decreased cefpodoxime effectiveness Details Sodium Bicarbonate Chloroquine Aralen® Decreased efficacy of chloroquine Details Sodium Bicarbonate Dasatinib Phyrago Reduced dasatinib exposure Details Sodium Bicarbonate Deflazacort Emflaza Decreased deflazacort effectiveness Details Sodium Bicarbonate Erlotinib Tarceva Reduced erlotinib exposure Details Sodium Bicarbonate Flecainide Tambocor® Flecainide toxicity (cardiac arrhythmias) Details Sodium Bicarbonate Folic Acid Folacin Reduced folic acid exposure and reduced efficacy of folic acid Details Sodium Bicarbonate Levothyroxine Ermeza Reduced efficacy of levothyroxine Details Sodium Bicarbonate Lithium Carbonate Lithobid Decreased lithium effectiveness Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.