Sorafenib

75 interactions 4 explained in plain English
Also sold as: Nexavar Nexavar®
About Sorafenib

Sorafenib is used to treat advanced renal cell carcinoma (RCC; a type of cancer that begins in the kidneys). Sorafenib is also used to treat hepatocellular carcinoma (a type of liver cancer) that cannot be treated with surgery and a certain type of thyroid cancer that has spread to other parts of the body and cannot be… Read the full Sorafenib drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketoconazole Topical Felbamate Sertraline Levofloxacin Injection Eribulin Injection Oxaliplatin Injection
1 Contraindicated 68 Major 6 Moderate
All (75) Contraindicated (1) Major (68) Moderate (6)

Major

Sorafenib Amitriptyline Elavil Explained An increased risk of QT interval prolongation Details Sorafenib Sertraline Explained An increased risk of QT interval prolongation Details Sorafenib Buprenorphine Belbuca Explained An increased risk of QT interval prolongation Details Sorafenib Relugolix Orgovyx Explained Increased risk of QT interval prolongation Details Sorafenib Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Sorafenib Arsenic Trioxide Trisenox An increased risk of QT interval prolongation Details Sorafenib Aripiprazole Injection Abilify An increased risk of QT interval prolongation Details Sorafenib Arsenic Trioxide Injection Trisenox An increased risk of QT interval prolongation Details Sorafenib Asenapine Transdermal Patch Secuado An increased risk of QT interval prolongation Details Sorafenib Azathioprine Azasan An increased risk of hepatotoxicity Details Sorafenib Azithromycin AzaSite An increased risk of QT interval prolongation Details Sorafenib Alfuzosin UroXatral An increased risk of QT interval prolongation Details Sorafenib Anagrelide Agrylin Increased risk of QT interval prolongation Details Sorafenib Bedaquiline Sirturo Increased risk of QT interval prolongation Details Sorafenib Chloroquine Aralen® An increased risk of QT interval prolongation Details Sorafenib Dasatinib Phyrago An increased risk of QT interval prolongation Details Sorafenib Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Sorafenib Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Sorafenib Disopyramide Norpace An increased risk of QT interval prolongation Details Sorafenib Dofetilide Tikosyn An increased risk of QT interval prolongation Details Sorafenib Dolasetron Anzemet An increased risk of QT interval prolongation Details Sorafenib Dolasetron Injection Anzemet An increased risk of QT interval prolongation Details Sorafenib Encorafenib Braftovi Increased risk of QT interval prolongation, reduced SORAfenib exposure and reduced antitumor activity of sorafenib Details Sorafenib Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Sorafenib Eribulin Injection Halaven An increased risk of QT interval prolongation Details Sorafenib Famotidine Calmicid An increased risk of QT interval prolongation Details Sorafenib Famotidine Injection Calmicid An increased risk of QT interval prolongation Details Sorafenib Felbamate Felbatol An increased risk of QT interval prolongation Details Sorafenib Flecainide Tambocor® An increased risk of QT interval prolongation Details Sorafenib Foscarnet Injection Foscavir Increased risk of QT interval prolongation Details Sorafenib Fostemsavir Rukobia Increased risk of torsade de pointes Details Sorafenib Galantamine Razadyne An increased risk of QT interval prolongation Details Sorafenib Gatifloxacin Ophthalmic Zymar® An increased risk of QT interval prolongation Details Sorafenib Gemifloxacin Factive An increased risk of QT interval prolongation Details Sorafenib Glasdegib Daurismo Increased risk of QT interval prolongation Details Sorafenib Goserelin Implant Zoladex Increased risk of QT interval prolongation Details Sorafenib Granisetron Transdermal Patch Sancuso An increased risk of QT interval prolongation Details Sorafenib Granisetron Injection Granisol An increased risk of QT interval prolongation Details Sorafenib Histrelin Implant Supprelin Increased risk of QT interval prolongation Details Sorafenib Hydroxychloroquine Plaquenil Increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.