Sorafenib

Name: Sorafenib Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

75 interactions 4 explained in plain English

Also sold as: Nexavar Nexavar®

About Sorafenib

Sorafenib is used to treat advanced renal cell carcinoma (RCC; a type of cancer that begins in the kidneys). Sorafenib is also used to treat hepatocellular carcinoma (a type of liver cancer) that cannot be treated with surgery and a certain type of thyroid cancer that has spread to other parts of the body and cannot be… Read the full Sorafenib drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketoconazole Topical Felbamate Sertraline Levofloxacin Injection Eribulin Injection Oxaliplatin Injection

1 Contraindicated 68 Major 6 Moderate

All (75) Contraindicated (1) Major (68) Moderate (6)

Moderate

Sorafenib Dexamethasone Injection Decadron Decreased sorafenib concentrations Details Sorafenib Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Decreased sorafenib concentrations Details Sorafenib Docetaxel Beizray Increased docetaxel exposure and plasma concentrations Details Sorafenib Docetaxel Injection Beizray Increased docetaxel exposure and plasma concentrations Details Sorafenib Doxorubicin Adriamycin Increased exposure to DOXOrubicin Details Sorafenib Levothyroxine Ermeza Increased risk of hypothyroidism Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.