Sorafenib

Name: Sorafenib Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

75 interactions 4 explained in plain English

Also sold as: Nexavar Nexavar®

About Sorafenib

Sorafenib is used to treat advanced renal cell carcinoma (RCC; a type of cancer that begins in the kidneys). Sorafenib is also used to treat hepatocellular carcinoma (a type of liver cancer) that cannot be treated with surgery and a certain type of thyroid cancer that has spread to other parts of the body and cannot be… Read the full Sorafenib drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketoconazole Topical Felbamate Sertraline Levofloxacin Injection Eribulin Injection Oxaliplatin Injection

1 Contraindicated 68 Major 6 Moderate

All (75) Contraindicated (1) Major (68) Moderate (6)

Contraindicated

Sorafenib Ketoconazole Topical Extina® Foam Increased CYP3A4 substrate exposure and an increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.