Spirapril
39 interactions
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 11, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Aspirin
Aspirin Rectal
Irbesartan
Mercaptopurine
Cyclosporine Injection
Cyclosporine Ophthalmic
Major
Spirapril Aspirin Acuprin® Reduced hyponatremic and hypotensive effects of ACE inhibitors Details Spirapril Aspirin Rectal Aspirin Reduced hyponatremic and hypotensive effects of ACE inhibitors Details Spirapril Azathioprine Azasan Myelosuppression Details Spirapril Azilsartan Edarbi Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Spirapril Cyclosporine Injection Atopica Acute renal dysfunction and an increased risk of hyperkalemia Details Spirapril Cyclosporine Ophthalmic Cequa Acute renal dysfunction and an increased risk of hyperkalemia Details Spirapril Digoxin Cardoxin® An increased digoxin exposure Details Spirapril Eprosartan Teveten® Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Spirapril Everolimus Afinitor An increased risk of angioedema Details Spirapril Furosemide Injection Disal An increased risk of severe hypotension and deterioration in renal function, including renal failure Details Spirapril Irbesartan Avapro Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Spirapril Lithium Carbonate Lithobid Increased risk of lithium toxicity Details Spirapril Losartan Arbli Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Spirapril Mercaptopurine Purinethol® Myelosuppression DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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