Spirapril

39 interactions

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 11, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Aspirin Aspirin Rectal Irbesartan Mercaptopurine Cyclosporine Injection Cyclosporine Ophthalmic

14 Major 25 Moderate

All (39) Major (14) Moderate (25)

Moderate

Spirapril Asenapine Transdermal Patch Secuado An increased risk of hypotension Details Spirapril Bromfenac Ophthalmic Bromday® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Spirapril Capsaicin Arthricare for Women Moisturizing Increased risk of cough Details Spirapril Capsaicin Topical Aspercreme Warming® Increased risk of cough Details Spirapril Capsaicin Transdermal Patch Aspercreme Warming® Patch Increased risk of cough Details Spirapril Diclofenac Ophthalmic Voltaren® Eye Drops Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Spirapril Diclofenac Topical (Actinic Keratosis) Pennsaid Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Spirapril Diclofenac Topical (Arthritis Pain) Pennsaid® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Spirapril Diclofenac Transdermal Patch Flector Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Spirapril Etodolac Lodine Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Spirapril Fenoprofen Fenopron Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Spirapril Flurbiprofen Ansaid Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Spirapril Flurbiprofen Ophthalmic Ocufen Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Spirapril Ibuprofen Addaprin Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Spirapril Ketoprofen Actron® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Spirapril Ketorolac Acular Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Spirapril Ketorolac Injection Acular Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Spirapril Ketorolac Nasal Spray Sprix Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Spirapril Ketorolac Ophthalmic Acular Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Spirapril Meclofenamate Meclodium® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Spirapril Mefenamic Acid Ponstel® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Spirapril Meloxicam Alloxate Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Spirapril Meloxicam Injection Alloxate Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Spirapril Nabumetone Relafen Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Spirapril Naproxen Aleve Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.