Streptokinase and Aspirin Rectal: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Jul 11, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Aspirin Rectal
Streptokinase
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
An increased risk of hemorrhagic complications
Interaction Deep Dive
A post hoc analysis comparing streptokinase plus aspirin with streptokinase alone showed that the combined regimen increased fatalities from days 3 through 10 in patients who had experienced an ischemic stroke. The cause of death in the combination group was most often due to cerebral hemorrhagic complications1.
Why it happens (mechanism)
Prolongation of bleeding time
Literature reports
1 report — tap to read
a) A total of 156 patients with ischemic stroke were randomized to received streptokinase 1.5 MU plus aspirin 300 mg daily, while 157 patients with ischemic stroke received streptokinase alone. The two treatment groups were comparable for age, neurological severity, time after onset, and atrial fibrillation. The six-month case fatality was higher in patients who had received combination therapy (44%) than the patients who received streptokinase alone (28%). This difference was due to early deaths within the first three to ten days following the stroke, and death was mainly due to intracranial hemorrhage. The use of streptokinase without aspirin did not increase the risk of stroke recurrence. Although aspirin may be useful to prevent recurrence in acute ischemic stroke, it should be avoided until thrombolysis is accomplished 1.
Common questions
Can I take Streptokinase and Aspirin Rectal together?
An increased risk of hemorrhagic complications Always confirm with your pharmacist or prescriber before making any change.
How serious is the Streptokinase and Aspirin Rectal interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "delayed". Effects tend to build up gradually over days to weeks.
How strong is the evidence for this interaction?
The evidence is graded "established". Well documented — supported by controlled studies or strong clinical data.
Questions for your pharmacist
- Does my dose of Streptokinase or Aspirin Rectal need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (1)
- Ciccone A, Motto C, Aritzu E, et al: Negative interaction of aspirin and streptokinase in acute ischemic stroke: further analysis of the Multicenter Acute Stroke Trial-Italy. Cerebrovasc Dis 2000; 10:61-64. PubMed
Keep reading about Aspirin Rectal
Keep reading about Streptokinase
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