Streptokinase and Dipyridamole: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Dipyridamole
Streptokinase
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
An increased risk of bleeding
Interaction Deep Dive
Streptokinase has been shown to alter platelet function; therefore, concurrent use of drugs such as aspirin, indomethacin, dipyridamole, phenylbutazone, and other drugs known to significantly affect platelet integrity should be avoided12.
Why it happens (mechanism)
Increased anticoagulation effects
Common questions
Can I take Streptokinase and Dipyridamole together?
An increased risk of bleeding Always confirm with your pharmacist or prescriber before making any change.
How serious is the Streptokinase and Dipyridamole interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "rapid". Effects can appear quickly, often within about 24 hours of combining the drugs.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Streptokinase or Dipyridamole need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (2)
- Product Information: Streptase(R), streptokinase. Hoechst-Roussel Pharmaceuticals, Inc. Philadelphia, PA, 1994.
- Brogden RN, Speight TM, & Avery GS: Streptokinase: a review of its clinical pharmacology, mechanism of action and therapeutic uses. Drugs 1973; 5:357-445.
Keep reading about Dipyridamole
Keep reading about Streptokinase
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