Teriflunomide

31 interactions 1 explained in plain English
Also sold as: Aubagio Aubagio®
About Teriflunomide

Teriflunomide is used to treat adults with various forms of multiple sclerosis (MS; a disease in which the nerves do not function properly and people may experience weakness, numbness, loss of muscle coordination, and problems with vision, speech, and bladder control) including: clinically isolated syndrome (CIS; nerve… Read the full Teriflunomide drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Teriflunomide Simvastatin Flolipid Explained Increased exposure of OATP1B1/1B3 substrate Details Teriflunomide Acyclovir Avaclyr Increased exposure of OAT3 substrate Details Teriflunomide Acyclovir Injection Avaclyr Increased exposure of OAT3 substrate Details Teriflunomide Acyclovir Ophthalmic Avaclyr Increased exposure of OAT3 substrate Details Teriflunomide Acyclovir Topical Zovirax Increased exposure of OAT3 substrate Details Teriflunomide Alpelisib Piqray Increased alpelisib exposure and an increased risk of alpelisib-related adverse effects and toxicity Details Teriflunomide Asciminib Scemblix Increased BCRP substrate exposure and an increased risk of BCRP substrate-related adverse effects Details Teriflunomide Aztreonam Injection Azactam Increased risk of aztreonam exposure Details Teriflunomide Atorvastatin Atorvaliq Increased exposure of OATP1B1/1B3 substrate Details Teriflunomide Baricitinib Olumiant Increased exposure of OAT3 substrate Details Teriflunomide Cefaclor Ceclor® Increased exposure of OAT3 substrate Details Teriflunomide Daprodustat Jesduvroq Increased daprodustat exposure Details Teriflunomide Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Teriflunomide Furosemide Injection Disal Increased exposure of OAT3 substrate Details Teriflunomide Irinotecan Camptosar Increased exposure of BCRP substrate Details Teriflunomide Irinotecan Injection Camptosar Increased exposure of BCRP substrate Details Teriflunomide Leniolisib Joenja Increased BCRP substrate exposure Details Teriflunomide Letermovir Injection Prevymis Increased exposure of OATP1B1/1B3 substrate Details Teriflunomide Loperamide Diamode Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details Teriflunomide Methotrexate Jylamvo Increased exposure of methotrexate and increased risk of hepatotoxicity and bone marrow toxicity Details Teriflunomide Methotrexate Injection Abitrexate® Increased exposure of methotrexate and increased risk of hepatotoxicity and bone marrow toxicity Details Teriflunomide Methylergonovine Methergine Increased methylergonovine exposure Details Teriflunomide Montelukast Singulair Increased exposure of CYP2C8 substrate Details Teriflunomide Nifedipine Adalat® Increased NIFEdipine exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.