Tolbutamide

68 interactions 3 explained in plain English

Also sold as: Orinase®

About Tolbutamide

Tolbutamide is used along with diet and exercise, and sometimes with other medications, to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). Tolbutamide is in a class of medications called sulfonylureas. Tolbutamide lowers… Read the full Tolbutamide drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Moxifloxacin Asciminib Orlistat Insulin Glulisine (Rdna Origin) Injection Levofloxacin Injection Methotrexate Injection

35 Major 33 Moderate

All (68) Major (35) Moderate (33)

Major

Tolbutamide Acarbose Prandase® Explained An increased risk of hypoglycemia Details Tolbutamide Asciminib Scemblix Increased CYP2C9 substrate exposure and an increased risk of CYP2C9 substrate-related adverse reactions Details Tolbutamide Abiraterone Abirtega An increased risk of severe hypoglycemia Details Tolbutamide Capecitabine Xeloda Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Tolbutamide Chloroquine Aralen® Hypoglycemia Details Tolbutamide Delafloxacin Baxdela Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Tolbutamide Delafloxacin Injection Baxdela Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Tolbutamide Disopyramide Norpace Increased risk of hypoglycemia Details Tolbutamide Dulaglutide Injection Trulicity Increased risk of hypoglycemia Details Tolbutamide Entacapone Comtan Increased exposure of CYP2C9 substrate Details Tolbutamide Fluorouracil Adrucil Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Tolbutamide Fluorouracil Injection Adrucil Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Tolbutamide Fluorouracil Topical Carac Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Tolbutamide Furosemide Injection Disal An increased risk of hyperglycemia and an increased insulin requirement Details Tolbutamide Gatifloxacin Ophthalmic Zymar® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Tolbutamide Gemifloxacin Factive Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Tolbutamide Hydroxychloroquine Plaquenil Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Tolbutamide Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) An increased risk of hypoglycemia Details Tolbutamide Insulin Detemir (Rdna Origin) Injection Levemir An increased risk of hypoglycemia Details Tolbutamide Insulin Glulisine (Rdna Origin) Injection Apidra An increased risk of hypoglycemia Details Tolbutamide Lanreotide Injection Somatuline An increased risk of hypoglycemia and impaired glucose regulation Details Tolbutamide Levofloxacin Levaquin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Tolbutamide Levofloxacin Injection Levaquin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Tolbutamide Lixisenatide Injection Adlyxin® Increased risk of hypoglycemia Details Tolbutamide Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Tolbutamide Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Tolbutamide Moxifloxacin Avelox Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Tolbutamide Moxifloxacin Injection Avelox Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Tolbutamide Moxifloxacin Ophthalmic Moxeza® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Tolbutamide Octreotide Bynfezia An increased risk of hypoglycemia and impaired glucose regulation Details Tolbutamide Octreotide Injection Bynfezia An increased risk of hypoglycemia and impaired glucose regulation Details Tolbutamide Ofloxacin Floxin® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Tolbutamide Ofloxacin Ophthalmic Ocuflox Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Tolbutamide Ofloxacin Otic Floxin® Otic Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Tolbutamide Orlistat Alli An increased risk of hypoglycemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.