Tolbutamide

68 interactions 3 explained in plain English

Also sold as: Orinase®

About Tolbutamide

Tolbutamide is used along with diet and exercise, and sometimes with other medications, to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). Tolbutamide is in a class of medications called sulfonylureas. Tolbutamide lowers… Read the full Tolbutamide drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Moxifloxacin Asciminib Orlistat Insulin Glulisine (Rdna Origin) Injection Levofloxacin Injection Methotrexate Injection

35 Major 33 Moderate

All (68) Major (35) Moderate (33)

Moderate

Tolbutamide Lisinopril Prinivil Explained An increased risk of hypoglycemia Details Tolbutamide Aspirin Acuprin® Increased risk of hypoglycemia Details Tolbutamide Aspirin Rectal Aspirin Increased risk of hypoglycemia Details Tolbutamide Atenolol Tenormin Explained Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Tolbutamide Acebutolol Sectral® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Tolbutamide Benazepril Lotensin An increased risk of hypoglycemia Details Tolbutamide Alogliptin Nesina An increased risk of hypoglycemia Details Tolbutamide Betaxolol Betoptic S Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Tolbutamide Betaxolol Ophthalmic Betoptic® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Tolbutamide Bisoprolol Zebeta® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Tolbutamide Captopril Capoten® An increased risk of hypoglycemia Details Tolbutamide Chloramphenicol Injection Chloromycetin® Injection Hypoglycemia (CNS depression, seizures) Details Tolbutamide Clopidogrel Plavix An increased risk of hypoglycemia Details Tolbutamide Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia Details Tolbutamide Empagliflozin Glyxambi® (as a combination product containing Empagliflozin and Linagliptin) An increased risk of hypoglycemia Details Tolbutamide Enalapril Epaned An increased risk of hypoglycemia Details Tolbutamide Esmolol Brevibloc Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Tolbutamide Exenatide Injection Bydureon Increased risk of hypoglycemia Details Tolbutamide Fosinopril Monopril® An increased risk of hypoglycemia Details Tolbutamide Ketoconazole Topical Extina® Foam Hypoglycemia Details Tolbutamide Labetalol Normodyne® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Tolbutamide Levobunolol Ophthalmic AKBeta® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Tolbutamide Levothyroxine Ermeza Worsening of glycemic control Details Tolbutamide Linagliptin Tradjenta An increased risk of hypoglycemia Details Tolbutamide Linezolid Injection Zyvox An increased risk of hypoglycemia Details Tolbutamide Liraglutide Injection Saxenda An increased risk of hypoglycemia Details Tolbutamide Metformin Fortamet® An increased risk of hypoglycemia Details Tolbutamide Mitapivat Aqvesme Reduced CYP2C9 substrate exposure Details Tolbutamide Moexipril Univasc® An increased risk of hypoglycemia Details Tolbutamide Nadolol Corgard Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Tolbutamide Nebivolol Bystolic Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Tolbutamide Penbutolol Levatol® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Tolbutamide Perindopril Aceon An increased risk of hypoglycemia Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.