Drug Interaction Report

Turmeric and Betrixaban: Interaction Details

A pharmacist-reviewed analysis of the Turmeric and Betrixaban interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Jul 11, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Betrixaban

Bevyxxa®
+

Turmeric

No brand names on record
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Jul 11, 2026
Editorial policy · Data sources
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Interaction severity
Major
Potentially serious — often needs a change or close monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 18 documented Turmeric interactions, 18 are rated major — including this one.
Worried about symptoms right now? Contact your pharmacist or prescriber, or call Poison Control at 1-800-222-1222 (US). Call 911 for an emergency.
Onset
delayed
Evidence
probable
Severity
Major

What happens

An increased risk of bleeding

Interaction Deep Dive

Curcumin is a component of the food spice turmeric. Curcumin has antiplatelet activity, including platelet activation, aggregation, and adhesion1. Coadministration of anticoagulants and antiplatelet agents may increase the risk of bleeding. Promptly evaluate any signs or symptoms of blood loss that occur in a patient treated concomitantly 2.

Why it happens (mechanism)

Additive effects on hemostasis

Literature reports

1 report — tap to read

a) In a platelet aggregation study of blood samples obtained from healthy volunteers, curcumin was found to inhibit platelet aggregation induced by arachidonate, epinephrine, and collagen with IC50 values of 32 mcmol, 100 mcmol, and 344 mcmol, respectively. Curcumin (10,100, 500 mcmol) inhibited formation of thromboxane B2 dose-dependently (IC50 equal to 63 mcmol). The incorporation of labeled arachidonic acid into the platelet phospholipids was inhibited by 32 percent with curcumin 250 mcmol 3.

Common questions

Can I take Turmeric and Betrixaban together?

An increased risk of bleeding Always confirm with your pharmacist or prescriber before making any change.

How serious is the Turmeric and Betrixaban interaction?

It is rated major. Potentially serious — often needs a change or close monitoring.

How quickly could this interaction happen?

The documented onset is "delayed". Effects tend to build up gradually over days to weeks.

How strong is the evidence for this interaction?

The evidence is graded "probable". Good supporting evidence, though not definitively proven.

From our Q&A

Real reader questions about these medications, each personally answered by our pharmacist:

Questions for your pharmacist

  • Does my dose of Turmeric or Betrixaban need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there a safer alternative to one of these medications for me?

References (3)

  1. Hussain Y, Abdullah, Khan F, et al: Regulatory effects of curcumin on platelets: an update and future directions. Biomedicines 2022; 10(12):3180. PubMed
  2. Product Information: SAVAYSA(R) oral tablets, edoxaban oral tablets. Daiichi Sankyo Inc (per manufacturer), Basking Ridge, NJ, 2021. DailyMed
  3. Srivastava KC, Bordia A, & Verma SK: Curcumin, a major component of food spice tumeric (Curcuma longa) inhibits aggregation and alters eicosanoid metabolism in human blood platelets. Prostgland Leukotr Ess Fatty Acids 1995; 52:223-227.
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Betrixaban

Keep reading about Betrixaban

All Betrixaban interactions (207)
Also serious with: Venlafaxine Omadacycline Injection Verapamil Venetoclax
Turmeric

Keep reading about Turmeric

All Turmeric interactions (18)
Also serious with: Apixaban Fondaparinux Heparin Injection Enoxaparin Injection
Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Betrixaban + Activated Charcoal Danshen Piracetam St. John's Wort Aconite Allspice Aloe Alpha-lipoic Acid + 227 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

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This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.